The potential reasons why many patients with severe epilepsy still continue to experience seizures even after surgery has been described by researchers.

‘Preoperative abnormalities of two temporal lobe white matter tracts were identified in patients who had postoperative seizures but not in patients with no seizures after surgery.’

Unfortunately, approximately one in every two patients with TLE will
not be rendered completely seizure free after temporal lobe surgery,
and the reasons underlying persistent postoperative seizures have not
been resolved.




New research from the University of Liverpool, published in the journal Brain, has highlighted the potential reasons why many patients with severe epilepsy still continue to experience seizures even after surgery.
Reliable biomarkers
Understanding the reasons why so many patients continue to experience postoperative seizures, and identifying reliable biomarkers to predict who will continue to experience seizures, are crucial clinical and scientific research endeavors.
Researchers from the University's Institute of Translational Medicine, led by Neuroimaging Lead Dr. Simon Keller and collaborating with Medical University Bonn (Germany), Medical University of South Carolina (USA) and King's College London, performed a comprehensive diffusion tensor imaging (DTI) study in patients with TLE who were scanned preoperatively, postoperatively and assessed for postoperative seizure outcome.
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The results of these scans allowed the researchers to examine regional tissue characteristics along the length of temporal lobe white matter tract bundles. White matter is mainly composed of axons of nerve cells, which form connections between various grey matter areas of the brain, and carry nerve impulses between neurons allowing communication between different brain regions.
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Surgery outcomes
The researchers identified preoperative abnormalities of two temporal lobe white matter tracts that are not included in standardized temporal lobe surgery in patients who had postoperative seizures but not in patients with no seizures after surgery.
The two tracts were in the 'fornix' area on the same side as surgery, and in the white matter of the 'parahippocampal' region on the opposite side of the brain.
The tissue characteristics of these white matter tracts enabled researchers to correctly identify those likely to have further seizures in 84% of cases (sensitivity) and those unlikely to have further seizures in 89% of cases (specificity). This is significantly greater than current estimates.
The researchers also found that a particular temporal lobe white matter tract called the 'uncinate fasciculus' was abnormal - and potentially involved in the generation of seizures - in patients with excellent and suboptimal postoperative outcomes.
However, it was found that significantly more of this tract was surgically resected/removed in the patients with an excellent outcome.
New insights
Dr. Simon Keller, said, "There is scarce information on the prediction of postoperative seizure outcome using preoperative imaging technology, and this study is the first to rigorously investigate the tissue characteristics of temporal lobe white matter tracts with respect to future seizure classifications."
"Although there is some way to go before this kind of data can influence routine clinical practice, these results may have the potential to be developed into imaging prognostic markers of postoperative outcome and provide new insights for why some patients with temporal lobe epilepsy continue to experience postoperative seizures."
Source-Eurekalert