About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Why Do Beta Cells Refuse to Secrete Insulin in Uncontrolled Diabetes?

by Mohamed Fathima S on July 7, 2019 at 1:54 PM
Font : A-A+

Why Do Beta Cells Refuse to Secrete Insulin in Uncontrolled Diabetes?

Scientists have observed amazing cell interactions occurring in the pancreas. Based on the findings, the beta cells work as highly-connected clusters called islets and are coordinated by small teams of "leader cells" in response to rising glucose levels in the blood.

Due to the increasing insulin resistance of the cells, patients suffer from an increased blood sugar level with far-reaching consequences. After many years of illness, insulin production dries up and patients with type 2 diabetes have to inject insulin.

Advertisement


Previous work from co-author Professor Guy Rutter from Imperial College London and Professor David Hodson (now at Birmingham University in the UK) had provided evidence that this may be the case using isolated tissues. To show that this was also true in living animals including in zebrafish and mouse, the research teams developed an innovative imaging technique which allowed them to observe beta cells' hierarchical relationship "in vivo".

"In these model organisms we saw that when blood glucose levels increased, the response of beta cells originated from temporally defined leader cells. When we selectively deleted the leader cells, the level of coordination in subsequent responses to glucose was disrupted", explains CRTD PhD student Luis Delgadillo Silva, one of the two lead authors of the study. Mathematical analysis revealed that the leader cells have a controlling role over the islet. In addition, the researchers were able to show that some beta cells contained a unique molecular signature, which would allow them to be more metabolically active and perhaps more glucose-sensitive.
Advertisement

Based on their findings, the scientists will now aim to understand how important the leader cells are in the development of diabetes. "It's important for us to understand if the leader cells are vulnerable to damage as diabetes develops and, crucially, whether they can be targeted to maintain strong and healthy insulin responses to help cure the disease", explains Dr. Victoria Salem, senior clinical research fellow in the Section of Investigative Medicine at Imperial College London who co-led the UK study.

"To understand better the role of leader cells in islet function, we have established a set of new tools in zebrafish, which will help us to activate or silence beta cells by shining light on them, as well as to track individual cells over time. Using these tools, we will be able to ask precisely how many cells are controlled by a leader cell and what genes determine the identity of a leader cell", says Luis Delgadillo Silva.

The Scientists just published their results in the scientific journal Nature Metabolism, and are featured on the cover of the journal. The Dresden part of the study received funding from TUD / CRTD, the German Research Foundation, the Free State of Saxony, the German Center for Diabetes Research and the European Foundation for the Study of Diabetes.

Luis Delgadillo Silva is part of the research group of Dr. Nikolay Ninov. The team is investigating the beta cells of the pancreas as the key metabolic sensors and effectors for insulin release. They conduct their studies at the CRTD of TU Dresden, where top researchers from more than 30 countries are deciphering the principles of cell and tissue regeneration for disease diagnosis and treatment. The CRTD links laboratory and clinic, connects scientists with physicians, uses expertise in stem cell research, genome editing, and tissue regeneration - all for one goal: the cure of metabolic diseases such as diabetes, neurodegenerative diseases such as ALS, Alzheimer's and Parkinson's disease, hematological diseases such as leukemia, as well as eye and bone diseases using novel diagnostic tools and therapeutic options.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Monkeypox Outbreak: What it is, How Does it Spread & the Prevention
Seasonal Allergy Medications
How to Choose the Best Eczema-Friendly Moisturizer for Children?
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Diabetes - Essentials Parkinsons Disease Surgical Treatment Gestational diabetes Type 2 Diabetes Diabetes - Foot Care Diabesity Diabetes in Pets Diabetes Facts and Figures Insulin Hormone Hypoglycemia (Low Blood Sugar) 

Most Popular on Medindia

Pregnancy Confirmation Calculator Sanatogen Iron Intake Calculator Post-Nasal Drip Blood - Sugar Chart Drug Side Effects Calculator Vent Forte (Theophylline) Noscaphene (Noscapine) Hearing Loss Calculator Blood Pressure Calculator

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use