About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Why Cell 'Reproduction' Slows Down

by Tanya Thomas on July 27, 2010 at 11:03 AM
Font : A-A+

 Why Cell 'Reproduction' Slows Down

Scientists have figured why yeast cells, and maybe even other organisms' cells, are not able to go on producing copies of themselves forever.

Yeast cells, much like our own cells, have a finite ability to reproduce themselves.

Advertisement

A 'mother' cell can only produce 20-30 'daughters' before it loses the ability to replicate and dies.

Multidrug resistance (MDR) proteins are best known for helping cancer cells expel anticancer drugs.

Rong Li and colleagues at the Stowers Institute for Medical Research in Kansas City, Missouri, found that yeast lacking certain MDR proteins have a shorter reproductive lifespan; they produce fewer daughter cells.
Advertisement

Yeast engineered to contain more of these pumps, however, can produce more daughters.

Li and her colleagues found that yeast division also results in an unequal distribution of MDR proteins.

The mother cell retains the original MDR proteins while the bud gets young, newly formed MDR proteins. Because the mother's supply is never replenished, she has to rely on the pool of MDR proteins that she's born with, Li says.

Over time these proteins decay. Some lose only part of their function; others may stop working altogether.

We started to get the idea that "maybe these proteins are what's limiting the lifespan of these cells," Li says.

The team tested the idea that if the loss of MDR proteins does contribute to ageing, then cells that can't make these proteins should have shorter lifespans.

MDR proteins help rid cells of toxins, so as they begin to fail, toxins could accumulate even faster.

The study "raises the intriguing possibility that a similar mode of regulation could influence stem-cell senescence during human ageing," Nature quoted Matt Kaeberlein, at the University of Washington Medical School in Seattle, who investigates longevity in yeast, worms and mice, as saying.

It might also help explain why cancer cells, many of which are stuffed with MDRs, are seemingly immortal.

The latest study is published today in Nature Cell Biology.

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Get Involved and Stand Up for Human Rights on Human Rights Day 2022
Coronary Artery Bypass Grafting
Macronutrients Calculator for Weight Loss
View all
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Parkinsons Disease Surgical Treatment 

Most Popular on Medindia

Post-Nasal Drip Drug - Food Interactions Nutam (400mg) (Piracetam) The Essence of Yoga Daily Calorie Requirements Turmeric Powder - Health Benefits, Uses & Side Effects Hearing Loss Calculator Loram (2 mg) (Lorazepam) Sinopril (2mg) (Lacidipine) Noscaphene (Noscapine)
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Why Cell 'Reproduction' Slows Down Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests