A new Northwestern University study aims to answer a resilience puzzle: Why does a second-hand or indirect experience of neighborhood violence affect some youth, but not others?
"Little is known about the brain networks that are involved in shaping these different outcomes, a problem we pursue here," said Gregory E. Miller, lead author of the study and professor of psychology in the Weinberg College of Arts and Sciences at Northwestern.
Drawing on knowledge of the brain's intrinsic functional architecture, the researchers predicted that individual differences in resting-state connectivity would help explain variability in the strength of the association between neighborhood violence and cardiometabolic health.
The researchers tested 218 eighth-graders from the Chicago area for factors related to metabolic health, including obesity and insulin resistance. Assessing neighborhood factors, including murder rates, the researchers also conducted functional MRI (fMRI) scans of the brains of the study participants.
Consistent with predictions, resting-state connectivity within the central executive network emerged as a moderator of adaptation. Across six distinct outcomes, a higher neighborhood murder rate was associated with greater cardiometabolic risk, but this relationship was apparent only among youth who displayed lower CEN resting-state connectivity.
No such correlation was apparent, however, in youth that displayed high-resting functional connectivity in the same brain network. According to the researchers, the results suggest a role for the central executive network in adaptability and resilience to adverse events.
The study, due to its design (cross-sectional and observational), cannot claim a causal link between neighborhood violence and health, and the authors conclude that a longitudinal, multi-wave study is needed to track neighborhood conditions, brain development and cardiometabolic risk across childhood to establish causality.
"For basic scientists, these findings provide clues about the neural circuitries that facilitate or undermine adaptation," Miller said.
Further study could lead to possible interventions, which their preliminary evidence suggests could be "network training" programs to modulate the functional connectivity of the brain's CEN network. These network training programs can enhance "self-control, threat reappraisal and thought suppression" to lower at-risk teens' engagement in drug use, overeating and other reactions to such stress.
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