Patients with untreated white coat hypertension are twice as likely to die from heart disease than people with normal blood pressure, revealed new study led by researchers from Penn Medicine, published today in the Annals of Internal Medicine.
White coat hypertension, a condition in which a patient's blood pressure readings are higher when taken at the doctor's office compared to other settings, was originally attributed to the anxiety patients might experience during medical appointments. However, over the years, research has suggested the elevated readings might be a sign of underlying risk for future health problems. Researchers also found that patients with white coat hypertension who were taking medication to treat their high blood pressure, called antihypertensives, did not have an increased risk of heart disease or cardiovascular-related death compared to those with normal blood pressure readings.
"Studies suggest that about one in five adults may have white coat hypertension. Our findings underscore the importance of identifying people with this condition," said the study's lead author Jordana B. Cohen, MD, MSCE, an assistant professor in the division of Renal-Electrolyte and Hypertension and a senior scholar in the Center for Clinical Epidemiology and Biostatistics. "We believe individuals with isolated in-office hypertension - those who are not taking blood pressure medication - should be closely monitored for transition to sustained hypertension, or elevated blood pressure both at home and the doctor's office."
To identify the cardiovascular risks of white coat hypertension, the researchers conducted a meta-analysis of 27 studies, comprising more than 60,000 patients, that evaluated the health risks associated with the condition. They found that patients with untreated white coat hypertension had a 36 percent increased risk of heart disease, 33 percent increased risk of death and 109 percent increased risk of death from heart disease.
"Our findings support the pressing need for increased out-of-office blood pressure monitoring nationwide, as it's critical in the diagnosis and management of hypertension," Cohen said.
"Simultaneously, we advise individuals with untreated white coat hypertension to engage in lifestyle modifications, including smoking cessation, reduction in their alcohol intake, and making improvements to their diet and exercise regimens. We also caution providers not to over-treat individuals with white coat hypertension who are already on blood pressure medication, as this could lead to dangerously low blood pressures outside of the office and unnecessary side effects from medication."
Researchers noted that future studies are needed to investigate interventions to reduce the cardiac risk of white coat hypertension.
This work was supported, in part, by a grant from the National Institutes of Health (K23-HL133843). Additional Penn authors on the study include Matthew G. Denker, Debbie L. Cohen and Raymond R. Townsend.