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What Kinda Of Role Does Hippocampus Play In Amnesia Patients?

by Rishika Gupta on December 27, 2018 at 10:23 PM
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 What Kinda Of Role Does Hippocampus Play In Amnesia Patients?

The question of how memory is tied to the hippocampus will help the scientists understand how memory works and thereby help treat memory problems.

Drs. Christine N. Smith and Larry R. Squire, both with the VA San Diego Healthcare System and the University of California, San Diego, found that declarative memory--recalling facts and events--depends on conscious knowledge of what has been learned. The finding helps explain how the hippocampus controls the process of memory. They also showed that conscious knowledge is compromised in patients with damage to the hippocampus.


Smith sums up the findings by saying, "Our study shows that awareness is a key feature of declarative memory."

The results appeared in the Nov. 20, 2018, issue of the Proceedings of the National Academy of Sciences.

Past research has shown that damage to the medial temporal lobe (MTL), the brain region that contains the hippocampus, can cause problems with declarative memory. This type of memory, the ability to remember information about past facts and events, has been linked to the hippocampus. It is expressed through direct recollection.

Another type of memory--nondeclarative--refers to skill and habit learning, as well as any other types of learning, that are based on performance rather than recollection. Nondeclarative memory does not seem to be affected by MTL damage. For example, a person with MTL damage may still remember how to ride a bike, but might not remember what he or she did yesterday.

While scientists know that the hippocampus is involved in declarative but not nondeclarative memory, how exactly the hippocampus operates during memory acquisition is not well-understood.

According to Squire: "A central issue for understanding memory and memory disorders is the matter of classification. What kinds of memory are there, what are the characteristics of each kind, and what brain systems are important for each kind?"

One theory is that declarative memory is linked to conscious knowledge or awareness of what has been learned. Another theory suggests that memory is dependent on how the brain processes information, rather than on conscious knowledge. For example, the second theory suggests that the MTL is needed when learning associations of relationships between items, regardless of whether the person is aware of what he or she has learned.

To test these two competing theories, Smith and Squire recruited five memory-impaired patients with MTL lesions. The patients, with an average age of 63, had amnesia from different causes. Two became amnesic after a drug overdose and associated respiratory failure, one suffered ischemia (lack of blood to the brain) because of kidney failure and toxic shock syndrome, one had viral encephalitis, and one became amnesic with no known cause. Brain scans showed that these patients had smaller-than-normal hippocampus volume. The researchers also recruited six healthy people to serve as controls.

They assessed participants' memories using something called the manipulation effect. Participants are shown a picture they are familiar with that has either been altered in some way or remains the same.

According to the manipulation effect, people will spend more time looking at the section of a picture that has been changed than at the same section of an unaltered picture. But research has shown that the manipulation effect occurs only when participants know that a picture has been altered.

For the experiment, participants were shown 24 scenes for five seconds each. After a short break, they were shown the scenes again. After another break, they were shown the same 24 scenes, except that 12 had been changed and 12 remained the same. Changes were either an item being added to the scene or an item being removed. For example, in a scene of a moving truck in front of a building, the first picture showed a worker with a cart while in the second picture the worker had been removed.

The process was repeated with 24 different scenes in a second session. A computer tracked eye movements to record where in the pictures participants were looking.

During the third round, participants were told to look for possible changes. They were then asked to state whether each scene was the same or changed and to rank their confidence in that answer. Finally, participants were shown the changed scenes again and asked to describe what was changed and identify where in the picture the change occurred.

The results showed that patients with MTL lesions were "markedly impaired" at telling which scenes were changed. Specifically, control participants correctly identified an average of 16.5 out of 24 of the changed scenes, and 20.5 of the unchanged scenes. Patients identified only 8.4 changes and 18.4 repeated scenes. Controls were also more confident in their answers when they were correct than when they were incorrect, while patients showed the same level of confidence in correct and incorrect answers.

Patients were able to correctly identify a scene as changed, describe the change, and locate the section of the image that changed for only10.8 percent of the altered images. Controls did this for 60.4 percent of the images. Getting all three aspects of the change right was termed "robust knowledge."

Both controls and patients directed their eyes toward the change only when they had robust knowledge of the change. This showed that the manipulation effect is a function of conscious memory, according to Smith and Squire. This eye movement effect suggests that conscious knowledge is an important aspect of declarative memory and that the hippocampus supports the acquisition of this type of memory.

Smith explains the eye-movement data in this way: "When memory-impaired patients occasionally succeed at remembering a past event (measured in their eye movements), they also consciously remember the event. When the patients failed to remember (and eye movements showed no recognition), they were unaware of the past event. Our findings suggest that awareness of the past is a crucial and consistent feature of the kind of memory that depends on the hippocampus"

According to Squire, adding to the understanding of how memory works could help improve how doctors diagnose and treat memory problems. "Scientists often say that we want to fix the car, but it will help to know how the car works. As we learn more about memory, we move closer to being able to detect, prevent, and treat diseases and disorders that affect memory," he explains.

Source: Eurekalert


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