About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Weight Gain Linked to Lower Risk of Amyotrophic Lateral Sclerosis

by Colleen Fleiss on June 28, 2019 at 2:20 AM
Font : A-A+

Weight Gain Linked to Lower Risk of Amyotrophic Lateral Sclerosis

People who gain weight and have an increased body mass index (BMI) were found to have a lowered risk of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, according to a large study published in the online issue of Neurology®, the medical journal of the American Academy of Neurology.

ALS is a rare, progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. People with ALS lose the ability to initiate and control muscle movement, which often leads to total paralysis and death. The average life span after diagnosis is two to five years.

Advertisement


BMI is a measure of a person's body size based on their height and weight. People are considered underweight if they have a BMI lower than 18.5 kg/m2, healthy if it is between 18.5 and 24.9, overweight if they have a BMI of 25 to 29 and obese with a BMI 30 or higher.

"It is important to note that while our study found a link between high BMI and a lower risk of ALS, it is possible that genetics could make a person more likely to have both a low BMI and a higher risk of ALS without one causing another," said study author Ola Nakken, MD, of the University of Oslo in Norway. "People must not interpret the results of our study as a suggestion that gaining weight may prevent ALS. Plus, the health risks of having a high BMI would be greater than any protective effect."
Advertisement

For the study, researchers reviewed a Norwegian database that included BMI measurements for the majority of people living in Norway between 1963 and 1975. Researchers included nearly 1.5 million people in the study, identifying 2,968 people who later developed ALS over an average of 33 years. Many people in the database also completed follow-up surveys about lifestyle and health, including weight change.

Researchers found that for every five-point increase in BMI from the low-normal BMI range, from the start to the end of the study, there was a 17-percent lower risk of developing ALS later. Of the 468,853 people in the low-normal range, 1,002 people developed ALS, or 0.21 percent. Of the 139,158 people in the obese range, 182 people developed ALS, or 0.13 percent. After 50 years, participants had a 31-percent lower risk of developing ALS for every five-point increase in BMI.

Participants who gained the most weight had a 37-percent lower risk of ALS than those who didn't gain weight or lost weight. The results remained the same after adjusting for smoking, cholesterol levels and physical activity.

"While some cases of ALS are genetic, most cases do not appear to have a genetic cause, and an increasing body of evidence suggests that there may be a link between a fast metabolism that can lead to a low BMI and ALS," said Nakken. "Much more research is needed to further examine the relationship between BMI and ALS."

A limitation of the study was that most participants were white, so the results may not be the same for other populations.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Menstrual Disorders
Coffee May Help You Fight Endometrial Cancer
Fermented Skin Care
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Zone Diet Height and Weight-Kids Body Mass Index Exercise To Gain Weight Weight Loss Program For Men Battle of the Bulge Diabetes Type 2 and Its Link to Sugar-Sweetened Beverages Mantra to Prevent Childhood Obesity – Vigorous Physical Activity Quiz on Weight Loss Drugs Causing Weight Gain 

Recommended Reading
Amyotrophic Lateral Sclerosis (ALS)
Find out more about the degenerative disease- Amyotrophic lateral sclerosis....
Body Mass Index
The BMI calculator helps you assess your weight indicating if it is normal or if you are ......
How to Lose Weight?
Slide show which explains obesity causes and tips on how to lose weight. Exercising before ......
Test Your Knowledge on Amyotrophic Lateral Sclerosis (ALS)
Amyotrophic lateral sclerosis (ALS) is a neurological disorder which can reduce the life span of ......
Battle of the Bulge
The ‘battle of bulge’ is the toughest of all battles. Once you put on weight it is so difficult to g...
Body Mass Index
Body mass index (BMI) is a simple tool that is generally used to estimate the total amount of body f...
Diabetes Type 2 and Its Link to Sugar-Sweetened Beverages
Sugar-sweetened beverages contribute to metabolic syndrome leading to higher risk for type-2 diabete...
Drugs Causing Weight Gain
Medications are among the lesser-known yet common causes of weight gain. Switching over to a lesser ...
Exercise To Gain Weight
Are you underweight and want to know how to gain weight? Exercise or workouts can help you gain weig...
Mantra to Prevent Childhood Obesity – Vigorous Physical Activity
Being physically very active is the mantra to prevent pediatric obesity rather than concentrating ef...
Weight Loss Program For Men
Maintaining a food diary and keeping a track of what you eat is the best way to keep your weight und...
Zone Diet
The Zone Diet is a weight loss program with a ‘40:30:30’ plan for carbohydrates, fats and proteins ....

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
ASK A DOCTOR ONLINE
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)