Exposure to a popular herbicide increased the chances of diseases to the second generation offspring in rats.
Herbicide, also commonly known as weedkillers, are chemical substances used to control unwanted plants Washington State University researchers have found that a rat exposed to a popular herbicide while in the womb developed no diseases and showed no apparent health effects aside from lower weight.
But the grand-offspring of that rat did have more disease, as did a great-grand offspring third generation.
Exposure of pregnant rats to atrazine - a commonly used herbicide
Manufactured by Syngenta, the hormone-disrupting compound has been banned in Europe, where it was found contaminating water, while the Environmental Protection Agency permits its use in the U.S. It has been found in water systems serving 30 million Americans in 28 states, according to an Environmental Working Group survey of municipal water records.
After Skinner and his colleagues exposed pregnant female rats to the herbicide, their first generation of offspring showed no ill effects but weighed less than rats in a control group.
Rats bred from them had increased testis disease and altered sperm production, mammary tumors in both males and females, early-onset puberty in the males and lower-weight females. Their offspring--the great-grand offspring of the exposed rats--also had more testis disease, plus early onset puberty in females, hyperactivity and leaner male and female physiques.
When Skinner and his colleagues looked at sperm of the offspring, they found epimutations, or alterations in the methyl groups that stick to DNA and affect its activation.
"Observations indicate that although atrazine does not promote disease in the directly exposed F1 [first] generation, it does have the capacity to promote the epigenetic transgenerational inheritance of disease in subsequent generations," the researchers write.
The investigators also identified specific sets of epimutations that could lead to improved diagnosis of ancestral exposures and one's susceptibility to disease.
Earlier work by Skinner has found epigenetic effects from a host of environmental toxicants, connecting plastics, pesticides, fungicide, dioxin, hydrocarbons, the fungicide vinclozolin and the popular insect repellant DEET to diseases and abnormalities as many as three generations later.