Mathematical methodology used to assimilate data for weather forecasting could predict the spread of brain tumors, shows study published in BioMed Central's open access journal Biology Direct
The authors from the Arizona State University and the Barrow Neurological Institute, Arizona, USA, wanted to prove that mathematical methods used in weather prediction could be useful in clinical situations - not just in brain cancer, but also in other cancers and diseases. They chose to study glioblastoma multiforme (GBM), a malignant brain cancer.
GBM is the most common and most aggressive type of brain cancer. Despite treatment, average patient survival is less than 15 months from initial diagnosis, and it is largely resistant to chemo- and radiotherapy. GBM can quickly invade large, sensitive regions of the brain, which makes it almost impossible to remove via surgery and almost certain to recur afterwards. Because little progress has been made in this area, GBM is an important area to study, and is a particularly good cancer against which to test a mathematical model, as its dynamics involve complex geometry.
Data assimilation techniques were then used to update the state vector, i.e. the initial condition of the glioblastoma growth model, by combining new observations with one or more prior forecasts. They then measured the feasibility of the model in individual patient cases for making short-term (60-day) forecasts of GBM spread and growth.
Despite this being a preliminary study, the authors were successful in demonstrating the feasibility of LETKF for short-term, clinically relevant predictions of the growth and spread of malignant brain tumors. LETKF forecasting and data assimilation provides an accurate and computationally efficient way of updating the initial condition (state vector) of a complex spatiotemporal model with new quantitative measurements. The intelligent model can also take into account likely errors in model parameters and measurement uncertainties in magnetic resonance imaging.
Mark Preul, one of the leaders of the study, believes that LETKF should be considered for future efforts that use mathematical models for clinical purposes in individual patient cases. He said, "Though work remains before our approach can be seriously considered in clinical settings, an accurate forecast system for glioblastoma may prove useful for treatment planning and patient counseling."