About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Warning Signs and Potential Treatments for Multiple Sclerosis Revealed in New Research

by Kathy Jones on November 11, 2013 at 5:42 PM
 Warning Signs and Potential Treatments for Multiple Sclerosis Revealed in New Research

New research indicates that scientists are gaining a new level of understanding of multiple sclerosis (MS) and that this may lead to new treatments and approaches to controlling the chronic disease.

The research was released today at Neuroscience 2013, the annual meeting of the Society for Neuroscience and the world's largest source of emerging news about brain science and health.

Advertisement

MS is a severe, often crippling, autoimmune disease caused by the body's immune system attacking the nervous system. Today, more than two million people worldwide suffer from MS and other neuroinflammatory diseases. MS usually strikes in early adulthood and manifests with symptoms including vision loss, paralysis, numbness, and fatigue. The disease can be intermittent or progressive and currently has no cure.

Today's new findings show that:
• Scientists are one step closer to understanding how antibodies in the blood stream break past the brain's protective barrier to attack the optic nerves, spinal cord, and brain, causing the symptoms of neuromyelitis optica, a rare disease similar to MS. Understanding how the antibodies bypass the protective blood-brain barrier could provide new approaches to treating the disease (Yukio Takeshita, MD, PhD, abstract 404.09, see attached summary).
• A protein involved in blood clotting mightserve as an early detection method for MS before symptoms occur. Early detection of the disease could lead to more effective early treatments (Katerina Akassoglou, PhD, abstract 404.11, see attached summary).
• Low levels of a cholesterol protein correlate with the severity of a patient's MS in both human patients and mouse models. The finding suggests the protein, known to protect against inflammation, may protect against developing MS, and possibly even aid in the regeneration of damaged neurons. This research opens the door to cholesterol drugs as a possible new avenue for MS treatment (Lidia Gardner, PhD, abstract 404.01, see attached summary).
Advertisement

Other recent findings discussed show that:
• A type of immune system cell has been found to directly target and damage nerve cell axons, a hallmark of MS. This may reveal a target for new therapies (Brian Sauer, PhD, presentation 404.06, see attached speaker summary).
• While no treatments to rebuild cells damaged by MS currently exist, scientists have found that when exosomes — tiny, naturally occurring "nanovesicles" — are produced by dendritic cells and applied to the brain, they can deliver a mixture of proteins and RNAs that promote regeneration of protective myelin sheaths and guard against MS symptoms (Richard Kraig, MD, PhD, presentation 812.02, see attached speaker summary).

"The findings shown today represent real promise for the millions suffering from MS," said press conference moderator Jeffrey Rothstein of Johns Hopkins University and an expert in neurodegenerative diseases. "These studies are breakthroughs in understanding and treating a disease that remains uncured, difficult to diagnose, and for which it is very difficult to prevent progression."



Source: Eurekalert
Font : A-A+

Advertisement

Advertisement
Advertisement

Recommended Readings

Latest Research News

Brain Circuits That Shape Bedtime Rituals in Mice
New study sheds light on the intrinsic, yet often overlooked, role of sleep preparation as a hardwired survival strategy.
NELL-1 Protein Aids to Reduce Bone Loss in Astronauts
Microgravity-induced bone loss in space, can be reduced by systemic delivery of NELL-1, a protein required for bone growth and its maintenance.
Connecting Genetic Variants to the Alzheimer's Puzzle
Researchers establish connections between Alzheimer's-linked genetic alterations and the functioning of brain cells.
Gene Therapy Sparks Spinal Cord Regeneration
Team at NeuroRestore introduces a groundbreaking gene therapy that has effectively promoted nerve regrowth and reconnection, post spinal cord injury.
Unlocking the Gut Microbiome's Influence on Bone Density
Scientists aim to pinpoint particular functional pathways affected by these bacteria that may have an impact on skeletal health.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
MediBotMediBot
Greetings! How can I assist you?MediBot
×

Warning Signs and Potential Treatments for Multiple Sclerosis Revealed in New Research Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests