A study on whether therapy with granulocyte-macrophage colony stimulating factor (GM-CSF), an agent that functions as a white blood cell growth factor, would improve walking performance in patients with symptomatic peripheral artery disease (a form of vascular disease in which there is partial or total blockage of an artery, usually one leading to a leg or arm) was led by Joseph Poole, M.D., Ph.D., of the Emory University School of Medicine, Atlanta, and colleagues. "Peripheral artery disease (PAD) affects more than 8 million individuals in the United States. Although exercise, smoking cessation, antiplatelet therapy, cilostazol [a medication for PAD], statins, and revascularization are used to treat PAD, men and women with PAD have significantly greater functional impairment and faster functional decline than those without PAD. Stem and progenitor cell (PC) therapy that promotes neoangiogenesis [formation of blood vessels] is an emerging treatment modality in PAD," according to background information in the article. Progenitor cells are involved in vascular repair and regeneration. The phase 2, placebo-controlled study included 159 patients with intermittent claudication (pain in leg muscles, aggravated by walking and caused by an insufficient supply of blood). Participants were randomized to received 4 weeks of subcutaneous (under the skin) injections of GM-CSF (leukine), 3 times a week (n = 80), or placebo (n = 79). The researchers found that therapy with GM-CSF did not improve treadmill walking time, a measure of PAD severity at 3-month follow-up. "The improvement in a subset of secondary outcomes observed with GM-CSF suggests that GM-CSF may warrant further study in patients with claudication. In addition, further investigation is needed to investigate the variability of responsiveness to GM-CSF and its clinical significance."Source: Eurekalert << 'Mini-Kidney' Structures Generated from Human Stem Cells By... New Anti-cancer Therapy Based on Cell Division Developed By... >> Recommended Reading In Peripheral Artery Disease, Blood Growth Factor Boosts Effects Of Exercise A clinical study has shown that a blood cell growth factor can boost the effects of exercise in improving mobility for patients with peripheral artery disease. READ MORE Study Shows How Exercise Helps Patients With Peripheral Artery Disease While exercise has long been considered to be the single best therapy for peripheral artery disease, the way in which it worked was a mystery. READ MORE Inequality Observed in Quality of Care, Cost for Patients With Peripheral Artery Disease A new study reveals that the quality of care and cost depend on who is providing the treatment. READ MORE Body Types and Befitting Workouts Workout and diet which is well suited for a pear shaped body. READ MORE Claudication Pain and/or cramping in legs due to inadequate blood flow is referred to as claudication. Common cause of claudication is peripheral artery disease. READ MORE Leriche Syndrome A patient with Leriche syndrome suffers from claudication symptoms, impotence and decreased pulses in the lower limbs. READ MORE Otitis Media Middle ear infection, or otitis media, is a common type of infection that may or may not accompany the infections of nose and throat. It is the infection of any part of the middle ear. READ MORE Temporal Arteritis Giant Cell Arteritis (GCA) or Temporal Arteritis is a condition where arteries those supplying to the head region get inflamed. The causes of Temporal Arteritis are not known. READ MORE Walking As An Exercise People walk for many reasons ranging from pleasure to mental relaxation, finding solitude or for exercise. READ MORE Walking for Fitness and Weight Loss A few extra steps a day are enough to keep you fit. READ MORE Who Else Wants to Know How Walking Helps Heart and Brain? Walking early morning would improve your health as it helps heart and brain to function properly. Find more about its benefits for your body. READ MORE Most Popular on Medindia Find a Doctor Calculate Ideal Weight for Infants Drug Interaction Checker More News on: Otitis MediaParkinsons Disease Surgical TreatmentReiki and Pranic HealingBody Types and Befitting WorkoutsTemporal ArteritisWalking for Fitness and Weight LossWalking As An ExerciseLeriche SyndromeClaudicationWho Else Wants to Know How Walking Helps Heart and Brain?