About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Vulnerable Enzyme That can be Targeted to Kill Dangerous Pathogens Discovered

by Rajashri on August 30, 2009 at 12:35 PM
Font : A-A+

 Vulnerable Enzyme That can be Targeted to Kill Dangerous Pathogens Discovered

An enzyme, which is essential to many bacteria, can be targeted to kill dangerous pathogens, according to a collaborative study conducted by researchers from three institutions in the U.S..

Experts at Burnham Institute for Medical Research (Burnham), University of Texas Southwestern Medical Center and University of Maryland have also identified chemical compounds that can inhibit this enzyme, and suppress the growth of pathogenic bacteria.

Advertisement

Writing about their study in the journal Chemistry and Biology, the researchers say that their findings are essential to develop new broad-spectrum antibacterial agents to overcome multi-drug resistance.

Dr. Andrei Osterman, an associate professor in Burnham's ioinformatics and Systems Biology program, targeted the acterial nicotinate mononucleotide adenylyltransferase (NadD), an essential enzyme for nicotinamide adenine dinculeotide (NAD) biosynthesis, which has many crucial functions in nearly all important pathogens.
Advertisement

The bacterial NadD differs significantly from the human enzyme.

"It's clear that because of bacterial resistance, we need new, wide-spectrum antibiotics. This enzyme is indispensable in many pathogens, so finding ways to inhibit it could give us new options against infection," said Dr. Osterman.

The research team used a structure-based approach to search for low-molecular-weight compounds that would selectively inhibit bacterial NadD, but not the human equivalent, by screening, in silico, more than a million compounds.

In their experiments, they tested the best predicted compounds against Escherichia coli and Bacillus anthracis (anthrax), which led them to a handful of versatile inhibitory chemotypes, which they explored in detail.

Using protein crystallography, a 3D structure of the enzyme in complex with one of the inhibitors was solved providing guidelines for further drug improvement.

"This is proof-of-concept that NadD is a good target to create antibacterial agents. This knowledge will be useful for both biodefense and public health. The next step is to find better inhibitors. We do not have a silver bullet yet, but we are certainly hitting a golden target," said Dr Osterman.

The research was supported by a grant from the National Institute of Allergy and Infectious Diseases.

Source: ANI
RAS
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Printed Temperature Sensors help with Continuous Temperature Monitoring
Health Benefits of Giloy
Breast Cancer Awareness Month 2021 - It's time to RISE
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Food Preservatives - How Safe Are They? Food Safety for Health Candida Diet 

Recommended Reading
Mosquito Diseases
Mosquito-borne diseases, like malaria, filaria, dengue, etc are common in places conducive of ......
Conjunctivitis
Conjunctivitis or Pink Eye causes redness and soreness of the conjunctiva and is responsible for 1% ...
Boils - Treatment by Drugs
Diabetes patients have reduced immunity, which makes them more susceptible to skin infections like ....
Candida Diet
It is possible to reverse Candida infection through a strictly followed Candida diet plan. Candida d...
Food Preservatives - How Safe Are They?
Food preservatives are basically antimicrobials or anti-oxidants that help preserve food by destroyi...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use