About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Vitamin E may Decrease Cancer Risk in Cowden Syndrome Patients

by Sheela Philomena on September 18, 2012 at 1:31 PM
Font : A-A+

 Vitamin E may Decrease Cancer Risk in Cowden Syndrome Patients

Cowden syndrome patients may benefit from vitamin E, say Cleveland Clinic researchers.

Several genetic mutations are known to be present in Cowden Syndrome (CS) - a disease that predisposes individuals to several types of cancers, including breast and thyroid cancers. One type of mutation in the succinate dehydrogenase (SDH) genes may be responsible for cancer development, according to research by Charis Eng, M.D., Ph.D., Hardis Chair and Director of the Genomic Medicine Institute and Director of its Center for Personalized Genetic Healthcare at Lerner Research Institute, published today in Clinical Cancer Research.

Advertisement

Dr. Eng discovered that mutations in SDH genes, responsible for energy production, result in an accumulation of reactive oxygen species (ROS). These changes damage the cells and make them resistant to apoptosis - our bodies' natural method of weeding out cancerous cells.

However, when vitamin E was applied to the mutant cells, ROS accumulation decreased, as well as the accompanying cellular damage.

"These findings support the notion that vitamin E may be useful as an anti-cancer therapeutic adjunct or preventive agent, especially for CS patients harboring SDH mutations, and its protective properties should be further explored," said Dr. Eng.

CS predisposes individuals to several types of cancers - an 85 percent lifetime risk of breast cancer, a 35 percent risk for epithelial thyroid cancer, and increased risk of other cancers as well. Approximately one in 200,000 people are affected by CS.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Organ Donation Week 2022 - 'Take the Pledge to Save Lives'
Test your Knowledge on Heart Transplantation
Test Your Knowledge on Lung Transplantation
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Calcium and Vitamin Supplements Vitamin Supplements Vitamin C / Ascorbic acid Vitamin B6 Vitamin B9 Vitamin B-12 Cancer and Homeopathy Vitamin-F Anti-ageing and Benefits of Red Wine Cancer Facts 

Most Popular on Medindia

Vent Forte (Theophylline) Noscaphene (Noscapine) Color Blindness Calculator Calculate Ideal Weight for Infants Turmeric Powder - Health Benefits, Uses & Side Effects Daily Calorie Requirements Find a Doctor Pregnancy Confirmation Calculator Blood - Sugar Chart A-Z Drug Brands in India
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use