Individuals with certain variants in a gene involved in vitamin D metabolism might be at an increased risk of developing melanoma, according to a new study.
University of Padova researchers in Italy have found that a variant of Bsml gene, involved in vitamin D metabolism, may be linked to skin cancer.
Advertisement
Previous studies have shown that vitamin D in the body has significant protective effects against the development of cancer because it regulates cell growth, cell differentiation and cell death. It exerts its effects by binding to a receptor located within cells.
But owing to the genetic differences in this vitamin D receptor among individuals, investigators believe that different people have different levels of vitamin D activity within their bodies. Therefore, some individuals may naturally be able to achieve more vitamin D-related protection against cancer than others.
![The Skin]( "The Skin")
During the study, lead researchers Simone Mocellin and Donato Nitti reviewed the existing research investigating the association between common variants in the vitamin D receptor and the risk of melanoma.
Their analysis showed a significant association between melanoma risk and the BsmI gene.
"These findings prompt further investigation on this subject and indirectly support the hypothesis that sun exposure might have an anti-melanoma effect through activation of the vitamin D system," the authors wrote.
The study is reported in the November 1, 2008 issue of Cancer.
Source: ANI
SRM
Advertisement
During the study, lead researchers Simone Mocellin and Donato Nitti reviewed the existing research investigating the association between common variants in the vitamin D receptor and the risk of melanoma.
Their analysis showed a significant association between melanoma risk and the BsmI gene.
"These findings prompt further investigation on this subject and indirectly support the hypothesis that sun exposure might have an anti-melanoma effect through activation of the vitamin D system," the authors wrote.
The study is reported in the November 1, 2008 issue of Cancer.
Source: ANI
SRM
Advertisement
Advertisement
|
Advertisement
Recommended Readings
Latest Cancer News
The combination of the personalized cancer vaccine with ACT led to ovarian cancer control in few patients within a span of three months, stated study results.
Uncovering key kinases in tumor growth and invasion is crucial for improving targeted therapies in advanced-stage colorectal cancer.
The study findings validate metal-enhanced photo-oxidation for future metal-based anticancer drugs.
Mutations in 11 genes are linked to aggressive forms of prostate cancer, which may present novel therapeutic and therapy options.
Improved oral health, as indicated by the count of natural teeth and dental appointments preceding the diagnosis, correlated with enhanced head and neck cancer survival rates.
