Vitamin D deficiency is prevalent in patients with kidney failure. It's not clear how this affects patients after they receive a kidney transplant. To investigate, Frank BienaimĂ©, MD (UniversitĂ© Paris Descartes and INSERM and Assistance Publique Hopitaux de Paris) and his colleagues studied a group of 634 kidney recipients who underwent transplantation between January 2005 and June 2010.
The researchers found that low vitamin D levels measured at three months after transplantation were linked with lower kidney function and increased kidney scarring at 12 months post-transplant. Other hormones involved with mineral metabolism were not predictors of kidney function or scarring after one year.
"This result suggests that maintaining vitamin D concentration within the normal range would prevent renal function deterioration after renal transplantation," said Dr. BienaimĂ©. "Vitamin D supplementation, a simple and inexpensive treatment, may improve transplantation outcomes." He encouraged the design of randomized controlled trials to evaluate the potential of vitamin D supplements to maintain kidney function following transplantation.
Study co-authors include Delphine Girard, MD, Dany Anglicheau, MD, PhD, Guillaume Canaud, MD, PhD, Jean Claude Souberbielle, DPharm, Henri Kreiss, MD, Laure HĂ©lĂ¨ne NoĂ«l, MD, GĂ©rard Friedlander, MD, PhD, Caroline Elie, MD, PhD, Christophe Legendre, MD, and Dominique PriĂ©, MD, PhD.
Disclosures: The authors reported no financial disclosures.
The article, entitled "Vitamin D Status and Outcomes After Renal Transplantation," will appear online at jasn.asnjournals.org on March 28, 2013, doi: 10.1681/ASN.2012060614.
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