About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Vitamin D and Breast Cancer Risk

by Sheela Philomena on April 5, 2012 at 12:18 PM
Font : A-A+

 Vitamin D and Breast Cancer Risk

In African American women, variations in vitamin D receptor is associated with an increased breast cancer risk, shows study published in journal Breast Cancer Research.

When a team of researchers led by Dr Song Yao and Dr Christine Ambrosone, from Roswell Park Cancer Institute, compared levels of vitamin D in the blood of women with or without breast cancer they found that severe vitamin D deficiency in African American women was almost six times more common than in European American women. However, because low levels of vitamin D can also be caused by disease, or by treatment, the researchers decided to focus their studies on genetic variations in VDR and the enzymes responsible for breaking down vitamin D in the body.

Advertisement

The results showed that African American women with the highest levels of vitamin D also had a specific variation in VDR. Although this variation was present in European Americans, it was not associated with alteration in their levels of vitamin D. African American women with the specific variation associated with the higher levels of vitamin D, had half the risk of breast cancer than the women without it.

When the researchers looked in detail at the patterns of genetic variation for women with ER negative breast cancer, they found that seven SNPs, in the gene coding for CYP24A1, were associated with ER negative breast cancer risk, and that two of these seemed to account for the higher risk of ER negative breast cancer in African American women.
Advertisement

Dr Song Yao explained, "While it is difficult to determine the exact effect of low levels of vitamin D on the risk of developing breast cancer, our results show that these genetic variations, which contribute to the function of vitamin D, are strongly associated with ER negative breast cancer and may contribute to the more aggressive breast cancer features seen in African American women."

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
H1N1 Influenza Prevention in Children: What Parents Need to Know
Dietary Factors Responsible for Dihydrotestosterone (DHT) Production and Hair Loss
Test Your Knowledge About Chromosomes?
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Calcium and Vitamin Supplements Women and Cancer Breast Biopsy Rickets Pagets disease of the breast Mastitis Vitamin Supplements Vitamin C / Ascorbic acid Vitamin B6 Vitamin B9 

Most Popular on Medindia

Find a Doctor Calculate Ideal Weight for Infants Drug Interaction Checker Noscaphene (Noscapine) Turmeric Powder - Health Benefits, Uses & Side Effects Hearing Loss Calculator Diaphragmatic Hernia Pregnancy Confirmation Calculator The Essence of Yoga Iron Intake Calculator
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Vitamin D and Breast Cancer Risk Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests