Khan, who heads the Tehreek-e-Insaf political party, had set up the Shaukat Khanum Memorial Cancer Hospital and Research Centre (SKMCH&RC) in Lahore in 1994.
The state-of-the-art cancer centre was Khan's tribute to his mother Shaukat Khanum, who died of cancer.
Khan, who heads the Shaukat Khanam Memorial Trust and has striven to gather funds for the project since the past nine years, said in Karachi that work would begin later this year.
The American architect who had designed the Lahore hospital has also designed the Karachi facility.
--Edited IANS