About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Stress hormone is the bone of contention for Anxious Behavior in Mice

by Medindia Content Team on April 17, 2006 at 5:54 PM
Font : A-A+

Stress hormone is the bone of contention for Anxious Behavior in Mice

It has been revealed through a study by neuroscientists at Harvard Medical School and its affiliate Mclean Hospital that long-term exposure to stress hormone in mice directly results in the anxiety that often comes with depression. April issue of Behavioral Neuroscience, which is published by the American Psychological Association, has this article.

This would be helpful in treating depression in humans. It appears likely that long-term exposure to cortisol actually contributes to the symptoms of depression. Paul Ardayfio, PhD candidate, and Kwang-Soo Kim, PhD, were the lead researchers and got these results by exposing mice to both short-term and long-term durations of stress hormone, which in rodents is corticosterone. In humans, usually ongoing, chronic stress, such as caring for a spouse with dementia, rather than acute stress, has been associated with depression.

Advertisement

Using 58 mice, the researchers gave the hormone in drinking water so as not to confound the results with the stress of injection. Chronic doses were 17 to 18 days of exposure; acute doses were 24 hours of exposure. Compared with mice given stress hormone for a day, mice given stress hormone for more than two weeks took significantly longer to emerge from a small dark compartment into a brightly lit open field, a common behavioral test of anxiety in animals.

Stress hormone can cause anxiety, which appears with depression. The authors say, Our results suggest that chronically high levels of cortisol, which occurs in Cushing's disease and some subtypes of depression, can increase anxiety on the one hand and dull responses to external stimuli on the other may be adaptive, whereas chronic exposure has detrimental effects on brain and behavior.

Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Test Your Knowledge on Lung Transplantation
Baldness can be Cured and Prevented: let us see How!
Drinking Beer or Wine Every Day Could Cause Age-related Diseases
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Anxiety Disorder Palpitations And Arrhythmias Stress Relief Through Alternative Medicine Stress and the Gender Divide Andropause / Male Menopause Heart Attack- Lifestyle Risks Is Your Man Moody? Diabesity Tired All The Time Women More Prone to Road Rage 

Most Popular on Medindia

Color Blindness Calculator Drug Interaction Checker Selfie Addiction Calculator Blood Pressure Calculator Nutam (400mg) (Piracetam) Sinopril (2mg) (Lacidipine) Blood Donation - Recipients Hearing Loss Calculator Daily Calorie Requirements Noscaphene (Noscapine)
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use