About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Stem Cell Therapy For Heart Attack Found To Be Ineffective

by Medindia Content Team on March 1, 2006 at 5:53 PM
Font : A-A+

Stem Cell Therapy For Heart Attack Found To Be Ineffective

A recent study has now established that stem cell therapy for heart attack may not be as effective as it is claimed to be, when tested under rigorous conditions. German researchers have stated that bone marrow transplantation may not improve cardiac function following heart attack.

Over the past few years, very few topics have had the potential to attract the attention of public and scientists alike. One such is the controversial area of stem cell research and therapy. Day by the day, a number of studies are being published, highlighting the promise of stem cell therapy in the treatment of neurodegenerative disorders, hematological malignancies, injury, and many others.

Advertisement

Evidence is accumulating on the importance of stem cells in regeneration of cardiac tissue. It is even believed to lead to the development of new blood vessels after a heart attack. Mobilization of bone marrow stem cells can be achieved through stimulation of a growth factor protein, called granulocyte colony-stimulating factor (G-CSF).

The researchers conducted a randomized, double blind, placebo-controlled study (REVIVAL-2) to assess effect of G-CSF treatment in a large study population (114 patients) following a heart attack. All the study participants were diagnosed to have a ST-segment elevation, characteristic of acute myocardial infarction.
Advertisement

The patients had undergone angioplasty and other similar percutaneous coronary intervention procedures for opening up a narrowed coronary artery. They were assigned to receive either G-CSF or a placebo for 5 days following treatment. A daily dose of 10 ĩg/kg of the growth factor was given in the form of an injection.

Although G-CSF protein produced a satisfactory mobilization of bone marrow stem cells, the size of the infarct or the left ventricular function remained unaltered following a heart attack. Furthermore, no increased risk of restenois or other adverse cardiac events could be documented with G-CSF treatment.

The results of this study can be found in the latest issue of JAMA. This study also highlights need for caution about the direct application of experimental results to clinical practice, without careful analysis, that may lead to complications, not foreseen at the moment.

Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Quiz on Low-Calorie Diet for Diabetes
World Heart Day in 2022- Use Heart for Every Heart
Anemia among Indian Women and Children Remains a Cause of Concern- National Family Health Survey-5
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Chest Pain Cardiac Catheterization Heart Attack Diet Lifestyle and Heart Disease Coronary Artery Bypass Grafting Reiki and Pranic Healing Stress and the Gender Divide Heart Attack Facts Heart Heart Attack- Lifestyle Risks 

Most Popular on Medindia

Post-Nasal Drip A-Z Drug Brands in India Pregnancy Confirmation Calculator Vent Forte (Theophylline) Hearing Loss Calculator Iron Intake Calculator Sanatogen Drug Interaction Checker Accident and Trauma Care Loram (2 mg) (Lorazepam)
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Stem Cell Therapy For Heart Attack Found To Be Ineffective Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests