About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Trails to detect effective breast cancer drugs that reduces recurrences

by Medindia Content Team on February 24, 2006 at 10:31 AM
Font : A-A+

Trails to detect effective breast cancer drugs that reduces recurrences

A quest for new drug has started to determine and help patients to have a recurrence free survival after breast cancer surgery. The chemotherapy drugs docetaxel (Taxotere) and vinorelbine (Navelbine) are tested to analyze the outcomes.

It was previously reported by the Finnish researchers that patients who received infusions of trastuzumab (Herceptin) were less likely to get recurrences in the New England Journal of Medicine.

Advertisement

Dr. Heikki Joensuu, corresponding author and a physician at Helsinki University Central Hospital said that the breast cancer recurrence reduced by 42% during the first 3 years of follow-up among women treated with docetaxel when compared to those who received vinorelbine.

But on the other hand it was found that docetaxel was associated with more adverse effects such as allergic reactions, swelling and fever.

Joensuu and his colleagues conducted a study in more than a thousand women with breast cancer.
Advertisement

They gave them three cycles of either docetaxel or vinorelbine, followed by three cycles of other cancer drugs.

Then, a subgroup of 232 women was identified whose tumors had an amplified HER2/neu gene. This gene is known to be associated with cancers that grow and spread aggressively.

They were also assigned either to receive nine weeks of infusions of Herceptin or a placebo. By doing this the researchers were able to identify the best regime for recurrence-free survival.

The result of the study was that patients who received Herceptin had 58 % fewer cancer recurrences during the three-year follow-up than those who didn't get the drug. Previous studies also show that adjuvant trastuzumab [Herceptin] if taken for a course of one year reduces the rate of breast cancer recurrence by 50 % in women having HER2-positive breast cancer.

But it is not clearly understood about the optimal duration of the drug usage. Dr. Mark Pegram, director of the women's cancer program at the Jonsson Cancer Center at the David Geffen School of Medicine at UCLA said that if it is the short nine week regime that turns out to be ideal then it is great news. But still this question remains to be confirmed.

Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Tapping — A Proven Self-Applied Stress Intervention
Black Pepper as Preventive Measure Against Omicron
FODMAP Diet: A Beginner's Guide
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Women and Cancer Drug Toxicity Breast Biopsy Pagets disease of the breast Mastitis Cancer and Homeopathy Signature Drug Toxicity Breast Cancer Facts Cancer Facts Cancer 
Recommended Reading
Breast Biopsy
Breast biopsy involves removing a sample of breast tissue to determine whether it is cancerous or .....
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
Mastitis
Mastitis is a common cause of tenderness, swelling and pain in breast, owing to inflammation in the ...
Pagets disease of the breast
A detailed description of the Paget's disease of the breast, characteristic signs and symptoms, dete...
Women and Cancer
Cancer is one of the frequently talked about and most feared disease that falls under the genre of l...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
CONSULT A DOCTOR
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)