About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Adult and Children Have Varied Drug Metabolism

by Medindia Content Team on February 18, 2006 at 11:44 AM
Font : A-A+

Adult and Children Have Varied Drug Metabolism

A new study led by Ronald Hines, professor of pediatrics at the Medical College of Wisconsin said that adult and children have very different drug metabolism.

Both have different levels of chemicals (enzymes) in their body for the processing of the drug. These enzymes vary in concentration with age.

Advertisement

Hence this study suggests that more research is needed to understand how medicines affect the young.

This plays a vital role because certain drugs have to be tested specifically on children. Drug companies do not do these tests as they dislike the extra cost that has to be spent for these tests.
Advertisement

But the companies and drug manufacturers has to keep this in mind when it comes to certain issues such as drug effectiveness and safety during early life stages. The team studied about 14 different enzymes in children and adults.

They findings were very surprising because several of the enzymes varied in concentration at different ages.

One such is the protein CYP3A4, which helps to oxidize chemicals in the body. It was found that children in the age group of two years have around 20-50 % of the CYP3A4 when compared to the adults.

This has increased the growing concern about the lack of understanding of the effects of medicines on children.

A report by Lords select committee said that 90 % of medicines used in the treatment of newborn babies had not been tested on infants. Some of them are morphine and many anti-epileptic agents.

Hence in conclusion more number of studies has to be directed in the better understanding of the drug metabolism in children.

Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Know More About Mitochondria
Top 10 Foods for Decreasing DHT Production and Preventing Hair Fall
Alarming Cesarean Section Trends in India - Convenience or Compulsion of Corporate Healthcare
View all
Recommended Reading
News Archive
Date
Category
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Height and Weight-Kids Signature Drug Toxicity 

Most Popular on Medindia

The Essence of Yoga Turmeric Powder - Health Benefits, Uses & Side Effects Calculate Ideal Weight for Infants Selfie Addiction Calculator Pregnancy Confirmation Calculator Color Blindness Calculator Daily Calorie Requirements Nutam (400mg) (Piracetam) Diaphragmatic Hernia Find a Hospital
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
ASK A DOCTOR ONLINE

×

Adult and Children Have Varied Drug Metabolism Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests