Researchers have discovered two common genetical variants that increase the risk for developing chronic kidney disease.
Chronic kidney disease is a condition in which kidneys of the body are unable to function properly in maintaining the correct fluid and waste balance that is part of the metabolism practice. This leads to accumulation of wastes in the body that can lead to toxicity of the body. Chronic kidney disease can become a lifelong or fatal condition, if is not managed effectively.
Researchers of Johns Hopkins Bloomberg School of Public Health had found that a variant of gene Apolipoprotein E (APOE) called e2 allele is linked with increased risk of chronic kidney disease. The gene causes abnormalities in the plasma triglycerides that is a common part of malfunction of the kidneys. The APOE gene had also been associated with Alzheimer's disease and heart disease through previous studies. The variants of the gene perform differently on kidney functions. In comparison with the variant e3, the e4 clears the waste in the blood quicker, and e2 more slowly that leads to the build up of the waste products in the blood to cause moderate form of chronic kidney disease.
Reference: Journal of American Medical Association, June 2005