New Tool Being Tested to Halt Recurrence of Atrial Fibrillation

by Medindia Content Team on  December 14, 2006 at 7:18 AM Research News
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New Tool Being Tested to Halt Recurrence of Atrial Fibrillation
Clinical researchers at the University of Pennsylvania Health System are starting a trial utilizing a new mechanism to treat the heart when its electrical pulses essentially short-circuit, referred to as atrial fibrillation (A-Fib).

The biggest problem physicians run into with current therapies to cope with electrical rhythmic pumping problems in the heart, namely pulmonary vein isolation procedures, is that up until now, they've had to deliver the energy bursts to the tissue in a dot-by-dot catheter ablation procedure around the veins, almost like a string of pearls. "That can cause swelling, and when that swelling goes down, you may still have viable tissue left behind, gaps, where the electricity can still conduct itself or get through," explains David Callans, MD, director of the electrophysiology laboratory at the Hospital of the University of Pennsylvania and principal investigator of this study. "Now we have a mechanism to construct this barricade of lesions, to do an entire circular ablation, minimizing the potential for gaps behind in the pulmonary veins."

Cardiac electrophysiologists at Penn are now using a high intensity focused ultrasound (HIFU) ablation system. It's the first to deliver energy bursts forward in a complete circle, all at once, from outside of the vein. This invasive procedure is done in the lab with balloon catheters while the patient is awake but sedated.

Electrophysiologists use ablation procedures (involving intense heat on the area of the heart causing the rhythmic pumping problems) to turn pulmonary vein tissue into scar tissue so that it can no longer conduct electricity. When this is done in several locations, it can effectively stop the symptoms of atrial fibrillation, which affects as many as five million Americans. "Since this new system sits outside of the vein, and delivers energy forward rather than immediately around it, there is no damage to the inside of the vein. This maintains a normal blood flow. Plus, this new system could shorten the ablation procedure time which currently takes about four hours," adds Callans.

Penn -- which is the only trial site in Pennsylvania, and one of 15 nationally -- is now recruiting volunteers for the HIFU ablation system trial. If you're interested in participating, call 215-662-6052. This is a randomized trial in which some participants will receive ablation treatment with the HIFU system made by ProRhythm, Inc. while others will be treated with anti-arrhythmic medication. The patients in this trial must be symptomatic and the atrial fibrillation must start and stop on its own (it is not persistent).

Penn Medicine, which has one of the largest cardiac electrophysiology programs in the country, has been doing atrial fibrillation ablation procedures for the last several years. Callans states, "Ablation is definitely the future for treatment of atrial fibrillation. Everything else we currently use to treat A-Fib is flawed. So the ablation procedure itself has to improve, become more effective and safer. And one way we can do this is on the technology front by developing better tools. This trial may be a big part of that."

Source: Newswise

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