Techniques for analyzing protein interactions aid in detecting the molecular basis of diseases

More than 40 new peer-reviewed protocols have been added to the records of Cold Spring Harbor Protocols, an online journal, which publishes techniques used in a variety of biology laboratories.

Two methods for analyzing protein interactions have been described in the new collection. These techniques will be of immense help to several cell and molecular biologists especially those involved in detecting the molecular basis of human diseases. The journal's website: www.cshprotocols.org gives a free access to both these methods.

Given the importance of characterizing the molecular networks and signaling pathways that form the biological basis of all living organisms, techniques aimed at probing protein interactions have come to the forefront in recent years. The new methods published today by CSH Protocols will be useful for researchers seeking to identify the molecular partners--such as other proteins or DNA--to which specific proteins bind.

The featured protocols describe how proteins of interest can be labeled with detectable markers and then used to probe thousands of different DNA and protein sequences. The protein-DNA and protein-protein interactions that are identified will eventually be useful for tracking down the causes of diseases, as well as for designing new drugs to aid in their prevention and treatment.

The latest issue of CSH Protocols also includes a variety of other standard and specialized techniques that will be useful to many researchers. These include methods for synchronizing cell growth, investigating embryonic development, and preparing specimens for immunostaining.

Source: Eurekalert
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