About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

NSAIDs In First trimester Linked To Congenital Anomalies In Babies

by Medindia Content Team on August 25, 2006 at 11:03 AM
Font : A-A+

NSAIDs In First trimester Linked To Congenital Anomalies In Babies

The use of NSAID by women in their first trimester could be associated with cardiac abnormalities in babies.

Non-steroidal anti-inflammatory drugs, NSAIDs, Cardiac septal defects, Journal Birth Defects Research Part B, Trimester, Pregnancy, Case control, Congenital abnormality, Diabetes

Advertisement

Women who take non-steroidal anti-inflammatory drugs (NSAIDs) early in their pregnancies may be more likely to give birth to babies with congenital defects.

The findings of a new case controlled study has been published in the August issue of the journal Birth Defects Research Part B, which is published by John Wiley & Sons, states that congenital birth defects especially cardiac septal defects, could be associated with the use of NSAID by women in their first trimester. It was reported that article is also available online via Wiley Interscience www.interscience.wiley.com/
journal/bdrb.
Advertisement

Many pregnant women get prescriptions for NSAIDs during their first trimester, and even more--up to 15 percent--take over-the-counter versions of these drugs. Previous studies have shown that taking NSAIDs toward the end of a pregnancy can cause certain circulatory problems--premature closure of the ductus arteriosus and patent ductus arteriosus, but the risks related to early-pregnancy ingestion are less well defined.

To better understand the relationship between first trimester use of NSAIDs and congenital birth defects, researchers led by Anick Berard, Ph.D. of St. Justine Hospital in Montreal, conducted a population-based case-control study. They gathered information from three administrative databases in Quebec and included 36,387 pregnant women in their study. They determined which women had filled prescriptions for NSAIDs during their first trimester and which had babies diagnosed with a congenital abnormality in the first year of life. Based on information from previous studies, the primary outcome of interest was cardiac septal closure and related abnormalities.

For each infant diagnosed with a congenital abnormality, the researchers matched up to ten controls by date of conception and maternal age, region of residence, and diabetes status. They performed statistical analyses to uncover any associations between the congenital abnormalities and the mother's use of NSAIDs during the first trimester.

Among the 1056 women who filled a prescription for NSAIDs early in their pregnancy, 8.8 percent had babies with congenital anomalies. Of the 35,331 women who did not fill prescriptions for NSAIDs, 7 percent had congenital anomalies. The difference was more pronounced for cardiac septal abnormalities. Furthermore, the proportion of infants with multiple congenital anomalies among mothers who filled an NSAID prescription in the first trimester and those who did not was 16.1 percent vs. 14.2 percent respectively.

"Our analysis of data from the Medication and Pregnancy registry suggests that women who fill prescriptions for NSAIDs in the first trimester of pregnancy may be at greater risk of having children with congenital anomalies, particularly those related to cardiac septal closure," the authors conclude. "This is in accordance with previous findings, but needs to be replicated in other study populations."

(Source: EurekAlert)
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Goji Berries May Protect Against Age-Related Vision Loss
Tapping — A Proven Self-Applied Stress Intervention
Black Pepper as Preventive Measure Against Omicron
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Birth Defects Trimester of pregnancy Pregnancy and Exercise Pregnancy Colon Polyps Top Doīs and Donīts of Traveling While Pregnant Arthrogryposis DOOR Syndrome / Rare Genetic Disorder 
Recommended Reading
Arthrogryposis
Arthrogryposis or Arthrogryposis multiplex congenita (AMC) is not a specific diagnosis but a clinica...
Birth Defects
Birth defects are abnormalities that occur in babies which affect how the body looks, works or both....
Colon Polyps
A colon polyp is a fleshy growth on the inside of the colon, also called the large intestine. In gen...
DOOR Syndrome / Rare Genetic Disorder
DOOR syndrome is a rare genetic disorder marked by deafness, short or absent fingernails, abnormal d...
Pregnancy
Detailed look at Early pregnancy Symptoms and easy health solutions during 1st, 2nd and 3rd trimeste...
Top Doīs and Donīts of Traveling While Pregnant
Pregnancy and travel can be a safer bonding by following simple but proper precautions based on the ...
Trimester of pregnancy
Encyclopedia section of medindia explains in brief about confirmation of pregnancy in first ......

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
CONSULT A DOCTOR
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)