Findings confirm the existence of immunological synapses, microanatomical structures similar to those of nerve cells, in vivo.
Researchers at the Board of Governors' Gene Therapeutics Research Institute at Cedars-Sinai Medical Center have confirmed the existence of anatomical structures that channel information exchanges between a T cell and its target, an antigen-presenting brain cell, in laboratory rats. This immunologic synapse, or junction where signals are shuttled between two immune cells, has previously only been observed in cell cultures, in part because of the limitations of imaging and the rapid, touch-and-go nature of the communication itself.
According to the researchers, this work should settle the controversy over the existence and functional significance of mature immunological synapses in vivo during antiviral immune responses. The findings will allow further experimental exploration of immunological synaptic function during normal and pathological immune responses in vivo.