About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

A Protein from Primate may Save Humans from HIV !

by Medindia Content Team on August 13, 2006 at 2:31 AM
Font : A-A+

A Protein from Primate may Save Humans from HIV !

Protein can efficiently stop HIV virus from entering and infecting blood cells, according to researchers of the University of Central Florida. Advancement has made man to stop producing this protein that was produced by our predecessors.

HIV-1 has a technique to escape the antiviral drugs targeted against it. It does so by frequently getting mutated. But a research team led by Associate Professor Alexander Cole of UCF's Burnett College of Biomedical Sciences has demonstrated that over 100 days the virus develops only weak resistance to retrocyclin, a defense peptide still found in monkeys and lower primates.

Advertisement

If additional laboratory tests demonstrate only weak resistance, Cole will study how retrocyclin could be developed into a drug designed to prevent the HIV virus from entering human cells.

Cole is also working with Henry Daniell, a UCF professor of molecular biology and microbiology, to develop a way to grow retrocyclin through genetically engineered tobacco plants. The retrocyclin gene would be incorporated into the chloroplast genome of tobacco cells before the plants grow. Daniell has developed a similar approach to growing anthrax vaccine in tobacco plants.
Advertisement

An inexpensive way to produce the drug with only a small amount of tobacco would help to make it accessible in areas such as Southeast Asia, Africa and the Caribbean where the disease spreads most quickly.

"If we could develop retrocyclin in plants and produce enough of the drug cheaply, we could potentially save a lot of lives," Cole said.

Cole was recently awarded about $4 million of National Institutes of Health grants through 2011 for the HIV-1 research and similar studies. The grants were provided through the National Institute of Allergy and Infectious Diseases; National Institute of Child Health and Human Development; and the National Heart, Lung and Blood Institute.

Cole started his research into theta-defensins at the University of California, Los Angeles, before he moved to UCF in 2003. Drs. Otto Yang and Robert Lehrer, infectious disease specialists at UCLA, and researchers at the University of Pittsburgh and Emory University are collaborating with Cole.

There are three classes of defensin peptides, and most research around the world has focused on alpha and beta defensins, the two types that humans still make. Cole studies theta-defensins called retrocyclins, which are no longer made by humans or advanced primates such as chimpanzees. However, theta-defensins are more active against HIV-1 than the other two types of defensins and can be developed in laboratories, two features that suggest retrocyclins still could become an effective way to fight the virus.

HIV-1 is the most common form of the human immunodeficiency virus that causes AIDS. The disease is often transmitted sexually, and the drugs produced from Cole's research would be applied to the vagina in the form of a gel or cream. Many of the laboratory tests have shown that retrocyclin can prevent HIV-1 infection of human vaginal tissue.

Retrocyclin was still an effective inhibitor of HIV-1 even after 100 days of continuous exposure to human cells in a laboratory setting. Cole and his team are encouraged that only minimal resistance of the virus occurred during that time. Higher resistance levels make it more difficult to develop drugs to fight the virus because doses must be increased substantially over time.

The exact reason why resistance does not develop quickly with retrocyclin is unclear, but it may be a result of retrocyclin interacting with more than one target on both the cell and virus. Viruses that have to defeat more than one antiviral mechanism often develop resistance at a much slower pace.

The next phase of Cole's research will delve more into the mutations that HIV-1 can take in an effort to minimize them as much as possible. Many series of laboratory tests would need to be completed before clinical trials could begin no earlier than 2009.

Cole's findings were published in the June 1 issue of The Journal of Immunology, a top journal in the fields of immunology, molecular biology and microbiology.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Black Pepper as Preventive Measure Against Omicron
FODMAP Diet: A Beginner's Guide
Smallpox
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Oral Health And AIDS AIDS/HIV AIDS/HIV - Epidemiology AIDS/HIV - Clinical Features AIDS/HIV - Health Education AIDS/HIV - Prevention And Transmission AIDS / HIV - Treatment AIDS/HIV- Lab Tests and Faqs Prostitution: Fresh Stakes in the Oldest Trade HIV Symptom 
Recommended Reading
AIDS / HIV - Treatment
Encyclopedia section of medindia explains in brief about the treatment for AIDS/HIV...
AIDS/HIV
"AIDS is an epidemic disease, a potentially preventable, deadly infection for which there is no cure...
AIDS/HIV - Clinical Features
Encyclopedia section of medindia gives general info about HIV Clinical Features...
AIDS/HIV - Epidemiology
AIDS or HIV is an epidemic disease, a potentially deadly infection that can be prevented with preca...
AIDS/HIV - Health Education
Encyclopedia section of medindia gives general info about AIDS information and health education....
AIDS/HIV - Prevention And Transmission
Encyclopedia section of medindia explains in brief about the prevention for AIDS/HIV...
Oral Health And AIDS
AIDS has taken on massive proportions in modern times. It is estimated that over 15 million people a...
Prostitution: Fresh Stakes in the Oldest Trade
Prostitution has broadened its base to include street prostitution, massage brothels, gigolo outcall...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use