About Careers Internship MedBlog Contact us

Mutation in the Envelope Gene May Be the Reason for the Development of HIV Linked Cognitive Decline

by Medindia Content Team on July 27, 2006 at 9:38 AM
Font : A-A+

Mutation in the Envelope Gene May Be the Reason for the Development of HIV Linked Cognitive Decline

According to a research conducted by Satish K. Pillai, PhD, a staff research associate at SFVAMC and a postdoctoral fellow at the University of California, San Francisco it was found that HIV in the brain was genetically different from those present in the peripheral blood.

The patients suffered severe to moderate cognitive decline. The HIV in the brain showed the presence of a particular mutation in the HIV envelope gene. The study analysed about 18 HIV-positive subjects. The study results appear in the journal Brain. Pillai and his associates generated 456 nucleotide sequences of HIV from the blood and cerebrospinal fluid of the study participants. They chose to focus on the viral envelope gene, which interacts with receptors on the surfaces of host cells. 'That's the gene that's most likely to vary between tissues, because it evolves rapidly and allows the virus to dock with different cell types,' Pillai says.


According to Pillai, an analysis of the sequence data suggests that HIV is 'genetically compartmentalized' between the central nervous system (CNS) and the blood, 'which means that the virus is replicating in relative isolation in these tissues, with very little exchange of genetic information between the two populations.' The researchers also analyzed the sequences in search of a 'genetic signature' common to the CNS-specific viruses in all 18 individuals, recounts Pillai. They found such a pattern, consisting of four amino acids, within a subregion of the viral envelope gene known as the V3 loop.

'The identification of these signature mutations presents convincing evidence that HIV adapts to the local environment within the central nervous system and, moreover, that commonalities in this environment exist across individuals,' he asserts. Another mutation in the V3 loop appeared consistently in virus from study subjects who demonstrated the most severe cognitive impairment. This mutation was absent in sequences from subjects with little or no cognitive deficit. 'In other words,' says Pillai, 'there appears to be a particular HIV mutation that is associated with dementia.' He cautions that this result is 'suggestive, not conclusive,' because of the study's small sample size.

This information 'may be clinically relevant in terms of treatment,' Pillai explains. 'If we identify the quintessential neurotoxic variant of HIV, could we use that as a predictor of HIV dementia?' He says that such knowledge could also help care providers make 'guided therapeutic decisions - for example, the detection of particular viral genotypes may lead physicians to select for antiretroviral regimens that cross the blood-brain barrier into the CNS most efficiently.' Or, he speculates, 'we might actually try to design a drug to target these genetic variants that are responsible for the neurological damage.' Pillai notes that the issue of HIV dementia is particularly important in regions outside North America and Europe where state-of-the-art antiretroviral medications are not widely available and HIV infection frequently leads to dementia.

SFVAMC staff physician Joseph K. Wong, MD, associate professor of medicine at UCSF and senior author of the study, adds, 'In addition to the implications of this new knowledge for the 40 million people infected with HIV, this study may also contribute to our general understanding of viral encephalitis,' or brain inflammation caused by other viruses. 'These results suggest that specific features of viral components themselves, and not just the immune response to viral infection, may be responsible for direct damage to the nervous system.' Pillai says that even though the study included almost 500 gene sequences, it is still exploratory: 'We are now in the process of expanding this to a survey of 100 to 150 individuals.'

Source Eurekalert

News A-Z
What's New on Medindia
Alarming Cesarean Section Trends in India - Convenience or Compulsion of Corporate Healthcare
Quiz on Low-Calorie Diet for Diabetes
World Heart Day in 2022- Use Heart for Every Heart
View all
Recommended Reading
News Archive
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Oral Health And AIDS DNA Finger Printing AIDS/HIV AIDS/HIV - Epidemiology AIDS/HIV - Clinical Features AIDS/HIV - Health Education AIDS/HIV - Prevention And Transmission AIDS / HIV - Treatment AIDS/HIV- Lab Tests and Faqs Prostitution: Fresh Stakes in the Oldest Trade 

Most Popular on Medindia

Color Blindness Calculator Vent Forte (Theophylline) A-Z Drug Brands in India Sinopril (2mg) (Lacidipine) Calculate Ideal Weight for Infants Find a Hospital Blood - Sugar Chart Noscaphene (Noscapine) Blood Pressure Calculator Indian Medical Journals
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use

Mutation in the Envelope Gene May Be the Reason for the Development of HIV Linked Cognitive Decline Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests