According to the University of Minnesota scientists anti-angiogenics are compounds that are very effective against cancer.
They are tiny molecules which cut of the blood supply to the solid tumor. This prevents the growth of the tumor. The study results appear in the Journal of the National Cancer Institute. ‘This is a novel class of drugs that increases the potential for good, effective treatment for cancer patients with tumors,’ said Kevin Mayo, Ph.D., principle investigator and professor of biochemistry, molecular biology and biophysics at the University of Minnesota Medical School. There is currently a protein anti-angiogenic agent approved by the FDA for clinical use. These new tumor-targeting compounds were designed to mimic the functional part of an anti-angiogenic protein. But, because the compounds are not proteins themselves, they have the advantage of possibly being taken in pill form and being less costly to produce. In animal studies with mice, the compounds inhibited tumor growth by up to 80 percent, and in combination with chemotherapy tumors essentially disappeared. Although the compounds proved effective against solid tumors, researchers believe they have potential to treat liquid tumors as well, such as the type found in leukemia and other blood cancers. ‘Our next step is to treat people with the drug in FDA-approved clinical trials,’ said Mayo.
