About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Significant Advance in Treatment of Breast Cancer Reported

by Medindia Content Team on July 7, 2006 at 9:14 AM
Font : A-A+

Significant Advance in Treatment of Breast Cancer Reported

In what may be a significant advance for the treatment of breast cancer, researchers have discovered they can more effectively wipe out diseased tissue when standard chemotherapy is combined with a drug that shuts down certain molecular pathways involved in causing cancer.

In a multicenter clinical trial reported in the Jully, 2006 issue of the Journal of Clinical Oncology, women with locally advanced breast cancer were given an oral medication that inhibits an enzyme called farnesyltransferase, in addition to routine chemotherapy, before undergoing surgery. Farnesyltransferase is required to set in motion a series of molecular events involved in the development of cancer.

Advertisement

Analysis of the breast tissue taken at surgery showed no signs of cancer in a third of the patients.

"The findings are extremely encouraging," said Dr. Joseph Sparano, lead author of the study and director of the Breast Evaluation Center at the Montefiore-Einstein Cancer Center. "Eradication of cancer cells in breast tissue is a short-term endpoint that translates into a greater chance of cure in the long term. This combination of therapies definitely looks promising, and we are moving ahead with larger trials to confirm our results."
Advertisement

The study included 21 women with locally advanced breast cancer who were considered suboptimal candidates for surgery because of the advanced stage of their disease. They received standard chemotherapy, doxorubicin and cyclophosphamide, given intravenously once every two weeks for four treatments. After each chemotherapy treatment, they also received 200 mg of tipifarnib, which inhibits farnesyltransferase, twice a day for six days. All patients then underwent a mastectomy or a lumpectomy.

Pathological analyses of breast tissue retrieved from the surgeries showed no cancerous tissue in seven patients, or 33 percent of the women who received the treatment, compared with 5 to 10 percent expected with chemotherapy alone.

The researchers also demonstrated that tipifarnib inhibited farnesyltransferase in tumor tissue by an average of 90 percent. Farnesyltransferase is essential for activating proteins, such as one called Ras, that contribute to the growth of cancer cells.

"This important study suggests that the proliferation and survival of breast tumor cells from one third of the patients in our study depended on proteins that were activated by farnesyltransferase," said Dr. Said Sebti, coauthor of the study and associate director of the Moffitt Research Institute in Tampa, Florida.

"We believe that by switching off the farnesylation-dependent pathways we made the chemotherapy much more effective" said Dr. Sparano. "Our next step will be to combine tipifarnib with other types of standard chemotherapy in order to push the response rate even higher, and perform randomized trials that provide more definitive proof of the benefits of this treatment."

The trial was performed by the New York Cancer Consortium, a multicenter clinical trials group funded by the National Cancer Institute to evaluate the newest and most promising cancer treatments. Montefiore Medical Center is the lead institution for this group. Each year, approximately 200 patients are enrolled in clinical trials conducted by the Consortium. The work was also partially funded by a grant from the National Cancer Institute to Dr. Septi.

Montefiore Medical Center, The University Hospital and Academic Medical Center for the Albert Einstein College of Medicine, ranks among the top one percent of all US hospitals based on its investments in medical innovation and cutting-edge technology.

(Source: Newswise)
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
World Heart Day in 2022- Use Heart for Every Heart
Anemia among Indian Women and Children Remains a Cause of Concern- National Family Health Survey-5
H1N1 Influenza Prevention in Children: What Parents Need to Know
View all
Recommended Reading
News Archive
Date
Category
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Women and Cancer Breast Biopsy Pagets disease of the breast Mastitis Cancer and Homeopathy Breast Cancer Facts Cancer Facts Cancer Breasts - Structures and Types Breast Lumps 

Most Popular on Medindia

Daily Calorie Requirements Drug - Food Interactions The Essence of Yoga Pregnancy Confirmation Calculator Color Blindness Calculator Find a Doctor Blood - Sugar Chart Sanatogen Hearing Loss Calculator Sinopril (2mg) (Lacidipine)
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
CONSULT ONLINE WITH A DOCTOR

×

Significant Advance in Treatment of Breast Cancer Reported Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests