Researchers suggested that HPV vaccination were well tolerable and showed reduced infection in about 90% of the subjects.
In the past 20 years, advances in cellular, molecular and immunologic technologies have contributed to the discovery of the link between HPV and cervical cancer. Two types, HPV 16 and HPV 18 account for the development of 70% of all cervical cancer cases. Other types of HPV cause other types of cancers, including some vulvar and vaginal cancers in women and penile cancers in men. Approximately 50% of all sexually active women are infected with one or more high risk HPV types, and by age 50 at least 80% of women will have acquired genital HPV infection. Approximately 74% of new HPV infections occurred among individuals 15-24 years old.
Researchers at Harvard School of Public Health developed a computer-based model of various cancer-prevention policies and their research suggests that the most cost-effective approach would be to administer the vaccine to young girls starting at the age of 11-12 with conventional pap smears for cervical abnormalities beginning at a later age and less frequently than currently recommended. This model suggests that the absolute lifetime risk of cervical cancer would be reduced by 94 percent compared to no intervention at all.
'The possibility of preventing cervical cancer is both exciting and challenging,' writes author Michael E Pichichero, MD, in the article. 'HPV vaccination would produce health gains that would be worth the cost.'