About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Growth Factors Help Neurons to Reach Their Correct Destination

by Medindia Content Team on June 16, 2006 at 6:07 PM
Font : A-A+

Growth Factors Help Neurons to Reach Their Correct Destination

According to the researchers at the Salk Institute for Biological Studies during embryonic development it was found that nerve cells uncertainly produce tentacle-like protrusions. These are called axons which finally help the nerves reach their destination. They guide the nerve cells through a series of attractive and repulsive chemical. While several recent studies discovered molecules that repel motor neuron axons from incorrect targets in the limb, scientists at the Salk Institute for Biological Studies have identified a molecule, known as FGF that actively lures growing axons closer to the right destination.

Their findings appear in the June 15 issue of Neuron. 'The most important aspect of our finding is not necessarily that we finally nailed the growth factor FGF as the molecule that guides a specific subgroup of motor neurons to connect to the muscles that line our spine and neck,' says senior author Samuel Pfaff, Ph.D., a professor in the Gene Expression Laboratory, 'but that piece by piece, we are uncovering general principles that ensure that the developing nervous system establishes proper neuronal connections.'

Advertisement

Understanding how axons find their destinations may help restore movement in people following spinal cord injury, or those with motor neuron diseases such as Lou Gehrig's disease, spinal muscle atrophy, and post-polio syndrome. Failure to establish proper connectivity in the brain may also underlie autism spectrum disorders and mental retardation. The multitasking members of the FGF growth factor family regulate blood vessel formation, wound repair, lung maturation, and development of skeletal muscle, blood and bone marrow cells. The Salk study adds on more job to an already long list. 'Our study emphasizes that the nervous system does not necessarily rely on an entirely new set of molecules to govern axon navigation, but instead uses growth factors already involved in embryonic development in clever and novel ways,' Pfaff says. Skeletal muscle consists of thousands of muscle fibers, each controlled by one motor neuron whose cell body lies in the brain or spinal cord.

Connections between muscle and nerve cells are established embryonically when newborn neurons extend axons to 'wire' the appropriate muscle fiber. The wiring process is highly orchestrated -each motor neuron has already pledged allegiance to a particular muscle fiber before it reaches out to connect with its predetermined partner. But until now, scientists could only speculate how the invisible bond was formed. 'The question was how these motor neurons know where to go,' says Pfaff. 'It would be a disaster if you wanted to move your arm and instead bent your back.' Earlier studies suggested that muscles lining the spine sent out chemical cues as a siren song for specific motor neurons known as MMCm cells. But when attempts to identify the enticing substance failed, many started to doubt its existence.
Advertisement

After screening numerous candidates, the Pfaff team found not only that FGF is expressed in target muscle, but that FGF 'sensors,' known as FGF receptors, are expressed in MMCm motor neurons. Furthermore, MMCm axons could not 'hear' their muscle partner's call and failed to reach their destination in mouse mutants lacking the sensor molecule. Finally, using mice engineered to express a fluorescent protein in MMCm neurons, the investigators demonstrated that only the glowing neurons extended axons in the direction of target cells expressing FGF. 'After a lot of hard work, we narrowed it down to FGFs and showed that they were indeed the long sought-after mysterious substance,' says Pfaff. Neural stem cells can now be coaxed to develop into motor neurons in a test tube.

In that artificial environment, explains Pfaff, 'Most external cues that guide immature motor neurons during embryonic development will be missing.' Hence the need to identify axon guidance factors. He continues, 'It is not enough to make the right cell type, you need to connect them to the right target. Growth factors like FGF may be crucial to persuade and guide them towards the desired destination.'Additional contributors to this study included first author Ryuichi Shirasaki, Ph.D., a former postdoctoral fellow in Pfaff's lab and now a faculty member at Osaka University, Japan; postdoctoral fellow Joseph W. Lewcock, Ph.D.; and research assistant Karen Lettieri, both at Salk.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
World Heart Day in 2022- Use Heart for Every Heart
Anemia among Indian Women and Children Remains a Cause of Concern- National Family Health Survey-5
H1N1 Influenza Prevention in Children: What Parents Need to Know
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Parkinsons Disease Parkinsons Disease Surgical Treatment 

Most Popular on Medindia

How to Reduce School Bag Weight - Simple Tips Hearing Loss Calculator Diaphragmatic Hernia Drug Interaction Checker Nutam (400mg) (Piracetam) Sinopril (2mg) (Lacidipine) Sanatogen Loram (2 mg) (Lorazepam) The Essence of Yoga Calculate Ideal Weight for Infants
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Growth Factors Help Neurons to Reach Their Correct Destination Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests