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A Carrier Protein Associates With Human Insulin Resistance

by Medindia Content Team on June 15, 2006 at 3:47 PM
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A Carrier Protein Associates With Human Insulin Resistance

A study reports that low blood protein levels are found to be associated with reduced insulin resistance and thus risk of diabetes , metabolic syndrome and cardiovascular disease decreased.

A protein in blood called retinol-binding protein 4 (RBP4), when reduced by the effect of modified diet and good exercise programs proved to drop the risk factors of diabetes - finding reports.

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Dr. Barbara Kahn, chief of the division of diabetes, endocrinology and metabolism at Beth Israel Deaconess Medical Center, and a professor of medicine at Harvard Medical School in Boston finds that a substance closely bonded to insulin resistance and risk factors of heart disease.

Kahn's group of researchers found 'RBP4, a protein that transports vitamin A in the blood may be a cause for insulin resistance' from animal studies.
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Since animal studies proved the links of RBP4 and insulin resistance, researchers are keen to know about the same in humans. So 60 subjects of 3 groups from California, Sweden and Germany have given blood samples for the study.

The first group included lean people, obese people without diabetes and obese people with type 2 diabetes. The second group was made up of people who had normal glucose metabolism, impaired glucose metabolism or type 2 diabetes. The final group included non-obese people with a strong family history of type 2 diabetes.

First group lean people got an average of 24 micrograms per milliliter (mcg/ml), while the obese non-diabetics scored 39 mcg/ml and obese diabetics averaged 41 mcg/ml.

In the second group, people with normal glucose tolerance scored low RBP4 levels.

The third group of people, who weren't obese, had an average level of 31 mcg/ml, thus proving family history plays a major role in predisposing people to diabetes risk.

High levels of RBP4 were also found to be associated with a higher body mass index, elevated hip-to-waist ratio, higher triglyceride levels, decreased HDL cholesterol and increased blood pressure which results better factors of cardiovascular risk.

From the above study, RBP4 can be used as a screening test for diagnosing the risks of diabetes.

Dr. Stuart Weiss, an endocrinologist at New York University Medical Center says even a 15-minute walk can reduce insulin resistance and increase insulin sensitivity.

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