An experimental drug named Dasatinib, developed by Bristol-Myers Squibb company offers a valuable treatment against the signs and symptoms of chronic myeloid leukemia patients than the usual drug named Gleevec.
Patients, who are resistant to Gleevec drug can now be treated with dasatinib, which seems to regulate intolerance and complications of chronic myeloid leukemic patients - studies published in NEJM finds.
Advertisement
In the phase I clinical trials dasatinib overcome Gleevec resistance in about 68 of 84 patients studied - study leader, HHMI investigator Charles L. Sawyers, and colleagues at UCLA's Jonsson Comprehensive Cancer Center, reported.
People in all 3 stages of the disease such as chronic phase, the accelerated phase, and blast crisis respond to the new drug quite possibly, Sawyers says.
Sawyers said, 'Drug-related mutations are better understood by the application of experimental drug, dasatinib to subjects and even individual patient's mutation type were easily studied by scientists at Bristol-Myers Squibb'.
'How drug target mutation take place and whether molecular explanation of drugs has any role to play in it' all studied by the scientists, showing improvements in structural biology studies.
Due to being as a 'sloppier inhibitor' meaning - does not hold its target to such tight structural constraints, dasatinib differs from the drug Gleevec.
Sawyers added dasatinib proves its value to overcome kinase resistance in managing cancer patients and also keep rooting in other fields of medicine like molecular oncology and structural biology.
Advertisement
Sawyers said, 'Drug-related mutations are better understood by the application of experimental drug, dasatinib to subjects and even individual patient's mutation type were easily studied by scientists at Bristol-Myers Squibb'.
'How drug target mutation take place and whether molecular explanation of drugs has any role to play in it' all studied by the scientists, showing improvements in structural biology studies.
Due to being as a 'sloppier inhibitor' meaning - does not hold its target to such tight structural constraints, dasatinib differs from the drug Gleevec.
Sawyers added dasatinib proves its value to overcome kinase resistance in managing cancer patients and also keep rooting in other fields of medicine like molecular oncology and structural biology.
Advertisement
Advertisement
|
Advertisement
Recommended Readings
Latest Cancer News
More affected relatives, higher lung cancer risk; participants with affected mothers or siblings faced increased risk.
Colorectal cancer can be lowered by up to 7% by increasing dietary consumption of folate rich foods like spinach, broccoli or taking folate supplements.
The effects and mechanisms of microRNA-451a (miR-451a), which hinders the progression of gemcitabine-resistant biliary tract cancers, are under study.
The blood test pinpointed 13 proteins capable of distinguishing between early and late stages of pancreatic cancer.
A fatty acid present in dairy products, beef, and lamb called trans-vaccenic acid enhances immune cells' capacity to combat cancers.