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PAI-2 Plays a Pivotal Role in Eye Infections

by Medindia Content Team on May 17, 2006 at 12:31 PM
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PAI-2 Plays a Pivotal Role in Eye Infections

According to researchers at the University of Pennsylvania and Temple University Plasminogen Activator Inhibitor Type 2 (PAI-2) plays an important role in diseases of the eye. This is a protein which is founding skin and the tissue covering the eyes. The researchers, led by Mina Massaro-Giordano, M.D., of the University of Pennsylvania's Scheie Eye Institute, and Marcella Macaluso, Ph.D., of the Sbarro Institute for Cancer Research at Temple University (http://www.shro.org), published their study.

'Cytoplasmic and nuclear interaction between Rb family proteins and PAI-2: a physiological crosstalk in human corneal and conjunctival epithelial cells,' in Cell Death and Differentiation (http://www.nature.com/cdd).They recently presented their findings at the annual meeting of the Association of Research in Vision and Ophthalmology (ARVO) in Florida, which was attended by over 10,000 researchers. PAI-2, in either extracellular or secreted form, is a multifunctional protein that plays a role in cell differentiation, in prevention of programmed cell death, in the regulation of cell proliferation, in the inhibition of microbial proteinases and in the protection against stromal degradation.

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High levels of the PAI-2 protein are associated with a good prognosis in breast cancer, small cell lung, ovarian cancer, and inhibition of metastasis. PAI-2 also plays a role in inflammation on the surface of the eye. In their study, the Penn and Temple researchers demonstrate for the first time an interaction between PAI-2 and the tumor suppressing gene Rb2/p130 in the nucleus of the epithelial cells in the cornea and conjunctiva. According to the researchers, this interaction with Rb2/p130 and chromatin modeling enzymes may affect how PAI-2 is expressed. 'There is a different expression of the protein between the epithelium of the cornea and conjunctiva cells,' says Massaro-Giordano, an assistant professor of ophthalmology, cataract and refractive surgery at Scheie. 'This may help us understand the molecular mechanisms that dictate the different expression profiles of PAI-2 in human corneal and conjunctival epithelial cells.'

Source: Eurekalert
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