Verapamil Benefits Children With Newly-diagnosed Type 1 Diabetes

In kids with newly diagnosed type 1 diabetes (T1D), the drug verapamil which is used to treat high was found to have a positive effect on the pancreas. The findings are published in JAMA “The beneficial effect of verapamil observed in the trial is extremely exciting,” said Antoinette Moran, MD, the study’s principal investigator and professor at the University of Minnesota Medical School. “Although we don’t know whether the beneficial effect of verapamil on insulin secretion by the pancreas will be sustained once treatment was stopped at 12 months, we do know that better pancreas function in the first year is associated with better long-term outcomes in type 1 diabetes.”

Anti-Hypertensive Drug Improves Pancreas' Function

The University of Minnesota was one of six pediatric diabetes centers in the U.S. that participated in the study. The trial included 88 children 8 to 17 years old who started the trial within 31 days of their T1D diagnosis. Participants were monitored for known side effects of verapamil, including effects on the heart, blood pressure and liver function. The study found that verapamil was well tolerated and very few of these side effects occurred.

In addition to evaluating verapamil, the trial also assessed whether an intensive glucose management approach that included use of an automated insulin delivery system to try to get glucose levels as close to normal as possible could have a beneficial effect on the pancreas’ insulin secretion. As reported in a companion paper in JAMA, much better glucose levels were achieved with this approach compared with standard care that included use of continuous glucose monitoring; however, a benefit on the pancreas was not observed. Nevertheless, the glucose levels achieved could have long-term benefits in reducing complications of diabetes.

Funding was provided by JDRF, while Dexcom, Medtronic, and Tandem Diabetes Care provided devices and supplies used in the study.

Source-Eurekalert