About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Vegetable Compound Shields Rodents from Lethal Radiation Doses

by Sheela Philomena on October 15, 2013 at 10:55 AM
Font : A-A+

 Vegetable Compound Shields Rodents from Lethal Radiation Doses

A compound derived from cruciferous vegetables such as cabbage, cauliflower and broccoli was found to protect mice and rats from lethal doses of radiation, say researchers.

Their study, published today in the Proceedings of the National Academy of Sciences (PNAS) suggests the compound, already shown to be safe for humans, may protect normal tissues during radiation therapy for cancer treatment and prevent or mitigate sickness caused by radiation exposure.

Advertisement

The compound, known as DIM (3,3'-diindolylmethane), previously has been found to have cancer preventive properties.

"DIM has been studied as a cancer prevention agent for years, but this is the first indication that DIM can also act as a radiation protector," says the study's corresponding author, Eliot Rosen, MD, PhD, of Georgetown Lombardi Comprehensive Cancer Center.
Advertisement

For the study, the researchers irradiated rats with lethal doses of gamma ray radiation. The animals were then treated with a daily injection of DIM for two weeks, starting 10 minutes after the radiation exposure.

The result was stunning, says Rosen, a professor of oncology, biochemistry and cell & molecular biology, and radiation medicine. "All of the untreated rats died, but well over half of the DIM-treated animals remained alive 30 days after the radiation exposure."

Rosen adds that DIM also provided protection whether the first injection was administered 24 hours before or up to 24 hours after radiation exposure.

"We also showed that DIM protects the survival of lethally irradiated mice," Rosen says. In addition, irradiated mice treated with DIM had less reduction in red blood cells, white blood cells and platelets — side effects often seen in patients undergoing radiation treatment for cancer.

Rosen says this study points to two potential uses of the compound. "DIM could protect normal tissues in patients receiving radiation therapy for cancer, but could also protect individuals from the lethal consequences of a nuclear disaster."

Rosen and study co-authors Saijun Fan, PhD, and Milton Brown, MD, PhD, are co-inventors on a patent application that has been filed by Georgetown University related to the usage of DIM and DIM-related compounds as radioprotectors.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Can Weight Loss be Achieved by Drinking Water?
Can Exercise Counts Boost Your Life Counts? 
Prevent Hacking of Medical Devices: FDA Sounds Alarm
View all
Recommended Reading
News Archive
Date
Category
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Radiotherapy X-Ray Why Do We Eat - Nutrition Facts Diet Lifestyle and Heart Disease The Acid-Alkaline balance, Diet and Health Nails - Health and Disease Health benefits of bananas Radiation Hazards Acute Radiation Syndrome Nutritional Guard - Bottle Gourd 

Most Popular on Medindia

Sinopril (2mg) (Lacidipine) Nutam (400mg) (Piracetam) Calculate Ideal Weight for Infants Daily Calorie Requirements Vent Forte (Theophylline) Find a Hospital Drug Side Effects Calculator Color Blindness Calculator Selfie Addiction Calculator Turmeric Powder - Health Benefits, Uses & Side Effects

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
ASK A DOCTOR ONLINE