Developing vaccines in a fully synthetic form may help overcome the two main problems with current vaccines - preservation of vaccines and delivery by injections. This is the claim of a research team that demonstrates a fully synthetic Influenza-A vaccine as an example for future vaccine development. The vaccine protected mice from potentially lethal doses of swine flu and also worked on human cells when tested in the laboratory. ‘According to this study the two main problems with vaccines the safety of vaccines and the use of needles, can be avoided by developing fully synthetic vaccines. The research team demonstrated this new vaccine concept with a novel Influenza A vaccine.’ "Theoretically, this prototype synthetic vaccine would not require refrigeration and could sit on the shelf for years without going out of date," Professor Sewell said. "In addition to being expensive, maintaining a cold chain of delivery can be extremely difficult in remote areas of the globe. In hot places without reliable electricity, this can count for the majority of the cost of vaccines, and significant wastage." Taking the needle out of the equation would also make vaccinations simpler to administer, and a whole lot less frightening. "To be administered orally, vaccines need to be able to survive the acids and enzymes in our stomachs. A couple - including the polio vaccine - can do this, but most cannot," said Associate Professor Miles, Principal Research Fellow at the Australian Institute of Tropical Health and Medicine. The team showed the synthetic vaccine was hyper-stable in both stomach acid and human blood, meaning it could be taken orally. Promisingly, it was effective when administered orally to mice. To build their synthetic vaccine, the team used D-amino acids. "These are mirror images of the L-amino acids that are the building blocks of all proteins," Associate Professor Miles said. "While L-amino acids are common in nature, D-amino acids are rare. We were attracted to them because they're very stable, meaning these compounds are harder to break down." After trailing D-Amino acids in various combinations, the researchers selected a version that successfully provoked the immune system's T cells to launch a defensive attack, protecting the mice when they were later given swine flu. "We were very surprised at how flexible the immune system is in recognizing dangerous targets," Associate Professor Miles said. "It can't actually tell the difference between our antigen and a real-world fragment of swine flu. This suggests you can build vaccines out of anything you want as long as they 'look' like the real thing in three dimensions." While we might be a long way from taking our vaccines orally and at room-temperature, Associate Professor Miles says this proof-of-concept study shows exciting promise. "We have some further work to do in making these vaccines work across larger populations and against other bugs and possibly cancer," he said. "But what we have now is a promising platform for synthetic vaccine production. We hope these new concepts and advances will help make a significant contribution to health world-wide." Source: Eurekalert << Tooth Loss Risk in Moms Linked to Larger Families Genes Normally Expressed in The Retina are Involved in Medul... >> Recommended Reading Hib Vaccine The Hib vaccine protects children against infections like meningitis and pneumonia that are caused by the Haemophilus influenzae type b bacterium. READ MORE Vaccination for Children Vaccines are biological products that impart immunity to the recipient. Vaccines may be live attenuated, killed or toxoids. READ MORE Top 10 Vaccine Myths Debunked Childhood vaccination has saved many lives, yet lots more has to be done to increase awareness and eliminate myths regarding vaccines. READ MORE Traveling with Children Abroad? - Parents, Stay Alert! Traveling with children is always challenging as it involves careful planning. Here are some precautions that need to be taken when traveling abroad with kids. READ MORE Most Popular on Medindia The Essence of Yoga Drug Interaction Checker Indian Medical Journals More News on: Vaccination for ChildrenTop 10 Vaccine Myths DebunkedTraveling with Children Abroad? - Parents, Stay Alert!