About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Use of Rectal Artesunate for Severe Malaria Explored in Cochrane Review

by Kathy Jones on May 31, 2014 at 4:37 PM
Font : A-A+

 Use of Rectal Artesunate for Severe Malaria Explored in Cochrane Review

An independent review of the effects of pre-referral rectal artesunate for people with severe malaria was conducted by researchers from the Cochrane Infectious Diseases Group, hosted at LSTM. The review is published in the Cochrane Library.

The review follows a large trial of rectal artesunate in 2009 which led the World Health Organization to recommend its use.Severe malaria is a serious medical condition caused by infection with the Plasmodium parasite. It is treated by giving injections of antimalarial drugs, which need to be started as quickly as possible to reduce the risk of death and brain damage.

Advertisement

In some rural areas where malaria is common, injections are unavailable and people often die before reaching hospital. In these areas rectal artesunate could feasibly be administered by volunteers without formal healthcare training, to start treatment before transporting the patient.The Cochrane review authors searched extensively for other trials, but only the single trial from 2009 directly assessed pre-referral treatment.

This trial enrolled over 17,000 patients at various sites across Ghana, Tanzania and Bangladesh, and trained village volunteers to recognize the symptoms of severe malaria, administer rectal artesunate, and refer all patients to hospital.At the African sites, only children aged 6 to 72 months were enrolled and there were fewer deaths with rectal artesunate than with placebo. This expected finding was replicated in Asia, but complicated by the unexpected finding of more deaths with artesunate in older children (aged >72 months) and adults. The trial was well designed to minimize bias, but the number of deaths in the older age group was very low. Consequently, there is the possibility that this finding occurred by chance but without further trials neither the trial authors, nor the review authors were able to reliably explain this finding. Joseph Okebe, the lead author of the review said: "In rural areas without access to injectable antimalarials rectal artesunate probably reduces deaths in young children. However, the low quality evidence that it is harmful in older children and adults must be taken into account when formulating national policies on pre-referral treatment."



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Top 9 Reasons Why We Should Practice Kindness
Top 10 Vitamin B12 Foods for Vegetarians - Slideshow
Targeted Screening Program Beneficial for Prostate Cancer Screening
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Malaria-water Malaria Mosquito Diseases Crohns Disease Fever Malaria - Protection Strategies 

Most Popular on Medindia

Turmeric Powder - Health Benefits, Uses & Side Effects The Essence of Yoga Daily Calorie Requirements Drug - Food Interactions Vent Forte (Theophylline) Iron Intake Calculator Selfie Addiction Calculator Find a Doctor Accident and Trauma Care Indian Medical Journals

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use