About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Use of Bone Morphogenetic Proteins in Children's Spine Surgery

by Bidita Debnath on March 16, 2017 at 11:52 PM
Font : A-A+

 Use of Bone Morphogenetic Proteins in Children's Spine Surgery

Bone morphogenetic proteins, commonly used off-label to enhance pediatric spinal fusion (spinal arthrodesis), did not improve revision rates for pediatric spinal fusion, according to a study presented at the American Academy of Orthopaedic Surgeons Annual Meeting in San Diego.

"BMP is frequently used off-label for pediatric spinal fusions, yet children rarely have difficulty forming robust bone at the site of spinal fusion. There is no proof that BMP improves the quality of spinal fusion in children and adolescents," said lead study author Emily Dodwell, MD, MPH, a pediatric orthopedic surgeon at Hospital for Special Surgery (HSS), in New York City. "Although the rationale for using BMP is that it might improve bone healing and minimize the likelihood of further surgery, we found that BMP did not change the revision rate in children."

Advertisement


BMPs are naturally occurring proteins found in the body that promote the formation of bone. They can be produced, concentrated, and used in various therapies to help bone heal or fuse. In the case of spinal fusion, they are placed around the spine to help healing. BMP is approved in adults for various indications including lumbar spine fusion. While BMP is not FDA approved in children, studies have shown that BMP is used off-label in up to 17 percent of pediatric spinal fusions, but little is known about whether it improves outcomes. Spinal fusion is one of the most common elective pediatric orthopedic surgeries.

To shed light on the issue, researchers at HSS turned to the Statewide Planning and Research Cooperative System (SPARCS) database for New York state. SPARCS is a comprehensive all payer data reporting system of all hospital admissions and ambulatory surgery cases performed in New York State, with the exclusion of those performed in Veterans Affairs facilities or other federal hospitals. They identified 7,312 children and adolescents who underwent spinal fusion between 2004 and 2014. Of this group, 6.7 percent received BMP. Use spiked between 2008 and 2010, when 8.7 percent received the product. BMP was more likely to be used in children who were older, white, and of a higher socioeconomic status.
Advertisement

"We didn't find any improvement in mid to long-term outcomes," said Dr. Dodwell. "While we didn't find any serious mid- to long-term complications with the use of BMP, longer-term larger prospective studies would be needed to determine the safety and efficacy of BMP in children." She thinks the study's findings support caution in using BMP for spinal fusion in children.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
January is the Thyroid Awareness Month in 2022
Menstrual Disorders
Coffee May Help You Fight Endometrial Cancer
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Spondylosis Infantile Cortical Hyperostosis Kyphosis Magical Millets for Your Health Baby Food - Basics Nutrition IQ Renal Osteodystrophy / Mineral Bone Disorder Discogram / Discography 

Recommended Reading
Spine Surgery Reduces Pain Associated With Rheumatoid Arthritis in 82-Year-Old Patient
Doctors in Mumbai diagnosed a form of Rheumatoid Arthritis and conducted minimal invasive surgery .....
Anti-Clotting Medications Not Needed Following Spine Surgery
Most patients need nothing more than vigilant monitoring following a surgery and should be spared .....
Patients Dissatisfied With Outcomes of Opioid Use Prior to Spine Surgery
The use of opiod pain relievers has been linked to less improvement and higher levels of ......
Baby Food - Basics
The healthiest baby foods can be made at home. Products from big brands that claim to develop infant...
Discogram / Discography
Discogram is a diagnostic procedure in which x-ray dye or contrast material is injected into the dis...
Infantile Cortical Hyperostosis
Infantile Cortical Hyperostosis is a disease of unknown cause, where bizarre thickening of the corti...
Kyphosis
Kyphosis is a spinal disorder, which is derived from Greek word – 'kyphos' which means bowed or ben...
Magical Millets for Your Health
Millets are far more nutrient dense than wheat and rice. They are inexpensive and tasty too. Nutriti...
Renal Osteodystrophy / Mineral Bone Disorder
Renal Osteodystrophy which is referred to as Mineral Bone Disorder is a result of imbalance in calci...
Spondylosis
Encyclopedia section of medindia gives general information about Spondylosis...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
CONSULT A DOCTOR
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)