The United States Food and Drug Administration issued a ban on sales of e-cigarettes, cigars, pipe, tobacco and hookahs to those under 18 years.
The ban will go into effect in 90 days, according to the USFDA, which described the final rule -- issued after several years of study and debate -- as "historic."
"As cigarette smoking among those under 18 has fallen, the use of other nicotine products, including e-cigarettes, has taken a drastic leap," said Health and Human Services Secretary Sylvia Burwell.
Key aspects of the rule include barring the sale of e-cigarettes to minors online or in person, prohibiting the distribution of free samples and not allowing vending machines unless they are located in an adult-only facility.
The rule also requires manufacturers to get marketing approval for any products that came on the market after February 15, 2007, to show that their "products meet the applicable public health standard set forth in the law."
This review process "gives the agency the ability to evaluate important factors such as ingredients, product design and health risks, as well as their appeal to youth and non-users," said the FDA in a statement.
The FDA gained the power to regulate a wider range of tobacco products in 2009, with the passage of the Family Smoking Prevention and Tobacco Control Act.
A preliminary rule was issued in 2014, resulting in more than 135,000 public comments, an FDA spokesman said.
Traditional cigarette smoking has declined in recent decades, but youths are increasingly turning to e-cigarettes, which are battery-powered devices that heat a nicotine liquid -- and flavored cigars.
E-cigarette use among high-schoolers rose from 1.5 percent in 2011 to 16 percent in 2015 -- a more than 900 percent increase -- according to the US Centers for Disease Control and Prevention.
Last year, three million middle and high school students were current e-cigarette users.
Another recent study carried out by the FDA and the National Institutes of Health in 2013-2014, showed four out of five youths who use some form of tobacco also had tried a flavored tobacco product in the past month.