Abnormal levels of gut bacteria can be determined from urine samples of premature babies before the onset of necrotizing enterocolitis (NEC), states research. Increased level of Firmicutes or Enterobacteriaceae, and lacked the Propionibacterium found in healthy babies.
NEC is a common but devastating problem of premature babies - affecting about 10% of infants born at under 29 weeks, about a third will die. To find out what the difference is between babies who have NEC and those who do not, 35 premature babies from Cincinnati Children's Hospital Medical Center were investigated. In this study, which also involved researchers from Boston College, Miami University, and Broad Institute, eleven of the babies went on to develop NEC.
Babies who went on to develop NEC had a lower diversity of gut organisms between days 4-9 after birth. All of the babies with NEC also had unusual levels of specific bacteria. Babies whose NEC started early (between 7-12 days after birth) had abnormally high levels of Firmicutes while babies whose NEC started later (19-31 days) had high levels of Enterobacteriaceae. All of the affected babies lacked Propionibacterium usually found in healthy babies.
To make sure that these findings apply to preterm infants in general, the research team is now studying hundreds of infants in multiple hospitals.