About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Urine LAM-ELISA Cannot Diagnose for Pulmonary TB Independently

by Rajashri on August 30, 2009 at 12:38 PM
Font : A-A+

 Urine LAM-ELISA Cannot Diagnose  for Pulmonary TB Independently

LAM-ELISA may not be useful as an independent diagnostic test for pulmonary tuberculosis (TB), a trial has found.

Detailed in the open access journal BMC Infectious Diseases, the results suggest that it was only capable of identifying 50.7 per cent of TB cases.

Advertisement

Klaus Reither led a team of researchers from the Ludwig-Maximilians-University of Munich, Germany, the University College London, UK, and the NIMR-Mbeya Medical Research Programme, Tanzania, who tested LAM-ELISA in 291 Tanzanian patients suspected of having TB.

He said: "Only 35 out of 69 pulmonary TB cases, confirmed by smear microscopy and/or solid culture and/or liquid culture, showed at least one positive LAM-ELISA result. This 50.7 per cent sensitivity of the LAM-ELISA was disappointingly low. The specificity of 87.8 % also fell far short of expectations."
Advertisement

The LAM-ELISA detects lipoarabinomannan (LAM), a mycobacterium-specific lipopolysaccharide component of the bacilli's cell wall.

In active mycobacterial disease, LAM is released into the blood and passes the renal barrier without major changes - suggesting that its detection in urine should be a reliable diagnostic indicator.

Urine can be easily obtained, and its collection is often more culturally accepted than the collection of sputum or blood samples.

The LAM-ELISA might not have fulfilled the requirements for a stand-alone diagnostic test for pulmonary tuberculosis, but the researchers speculate that it may still be of some use.

"In our opinion, further investigations are needed to elucidate if the LAM-ELISA, in this stage of development, is valuable as a supplemental tool for the diagnosis of HIV-associated TB. This seems particularly important, when taking into consideration that TB is one of the most important opportunistic infections of HIV patients and that the sensitivity of smear microscopy in immunocompromised patients is low," they say.

Source: ANI
RAS
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Anemia among Indian Women and Children Remains a Cause of Concern- National Family Health Survey-5
H1N1 Influenza Prevention in Children: What Parents Need to Know
Dietary Factors Responsible for Dihydrotestosterone (DHT) Production and Hair Loss
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Tuberculosis AIDS/HIV Urinary Stones In Children Vesico-Ureteric Reflux Causing UTI in Children Diet for Kidney stones Silicosis Screening Tests for Tuberculosis 

Most Popular on Medindia

Blood Pressure Calculator Drug Interaction Checker Find a Doctor Selfie Addiction Calculator The Essence of Yoga Hearing Loss Calculator Daily Calorie Requirements Find a Hospital Calculate Ideal Weight for Infants Nutam (400mg) (Piracetam)
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Urine LAM-ELISA Cannot Diagnose for Pulmonary TB Independently Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests