About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Unique Mouse Model for the Study of Aplastic Anaemia Created by CNIO Team

by Kathy Jones on September 1, 2012 at 3:01 PM
Font : A-A+

 Unique Mouse Model for the Study of Aplastic Anaemia Created by CNIO Team

A reduction in the number of the bone marrow cells that go on to form the different cell types present in blood leads to a condition called aplastic anemia.

In most cases, the causes of the disorder are hard to determine, but some patients have been found to have genetic alterations leading to a shortening of their telomeres (the end regions of chromosomes that protect and stabilise DNA).

Advertisement

A team at the Spanish National Cancer Research Centre (CNIO) led by María Blasco has successfully created a transgenic mouse model that simulates the disease in humans. And its study has allowed them to demonstrate the process linking telomere impairment with the condition. Their results are published today in the online edition of the journal Blood.

Telomeres and stem cells

Telomeres consist of a repetitive DNA sequence bound to a series of proteins, including Trf1, which guard them from degradation and/or damage. Using transgenic techniques, Blasco's team have managed to eliminate the Trf1 protein from mouse bone marrow, in order to explore its role in the tissue's function.
Advertisement

They found that when Trf1 is eliminated, the mice develop exactly the same symptoms as aplastic anaemia sufferers: bone marrow failure with the corresponding pancytopenia (a reduction in the number of red and white blood cells, as well as platelets). Also, the authors have shown for the first time that the absence of this protein causes a shortening of the telomeres of blood cell-producing stem cells which leads, in turn, to the progressive stress-induced death of the remaining stem cells in the tissue and, eventually, the death of the animal.

This discovery establishes the molecular bases of certain genetic variants of aplastic anaemia and opens a new line of attack via Trf1 to prevent the telomere shortening and cell death that trigger the disease. "We have generated an animal model for aplastic anaemia associated with short telomeres that may aid in the design and testing of new therapeutic strategies," confirms Blasco. These findings may also offer insights into other processes linked to telomere length, such as ageing and cancer.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Test Your Knowledge on Lung Transplantation
Baldness can be Cured and Prevented: let us see How!
Drinking Beer or Wine Every Day Could Cause Age-related Diseases
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Anemia Anemia in Pregnancy Iron & Folate Deficiency Anemia In Pregnancy Diet for Anemia in Pregnancy 

Most Popular on Medindia

Find a Hospital Selfie Addiction Calculator Turmeric Powder - Health Benefits, Uses & Side Effects Indian Medical Journals Noscaphene (Noscapine) Post-Nasal Drip How to Reduce School Bag Weight - Simple Tips Drug Side Effects Calculator Blood - Sugar Chart Calculate Ideal Weight for Infants
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use