About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Unique Membrane Properties of Human Neocortical Neurons Enhance Signal Processing

by Dr. Trupti Shirole on January 6, 2017 at 10:21 AM
Font : A-A+

 Unique Membrane Properties of Human Neocortical Neurons Enhance Signal Processing

The first direct evidence for the unique electrical properties of human neurons has been provided by a new study.

The human brain's advanced cognitive capabilities are often attributed to our recently evolved neocortex. Comparison of human and rodent brains shows that the human cortex is thicker, contains more white matter, has larger neurons, and its abundant pyramidal cells (formerly called "psychic" neurons) have more synaptic connections per cell as compared to rodents.

Advertisement


However, scientists have yet to determine whether there are important differences at the biophysical level of the basic building blocks of the human neocortex, the pyramidal neurons. Do these cells possess unique biophysical properties that might impact on cortical computations?

To answer this question, a theoretical team led by Prof. Idan Segev from the Hebrew University of Jerusalem, working with experimental colleagues at Vrije Universiteit Amsterdam and Instituto Cajal in Madrid, built detailed 3D models of pyramidal cells from the human temporal neocortex. These first-ever detailed models of human neurons were based on in vitro intracellular physiological and anatomical data from human cells.
Advertisement

(To collect this data, fresh cortical tissue was obtained from brain operations at a neurosurgical department in Amsterdam, and additional data was obtained from light-microscope studies in pyramidal cells from post mortem studies at the Cajal Institute in Madrid.)

The theoretical study predicted that layer 2/3 pyramidal neurons from the human temporal cortex would have a specific membrane capacitance that is half of the commonly accepted "universal" value for biological membranes (~0.5 μF/cm2 vs. ~1 μF/cm2). Since membrane capacitance affects how quickly a cell can respond to its synaptic inputs, this finding has important implications for the transmission of signals within and between cells. The theoretical prediction regarding the specific membrane capacitance was then validated experimentally by direct measurements of membrane capacitance in human pyramidal neurons.

Researcher Guy Eyal, a Ph.D. student at the Hebrew University's Department of Neurobiology, said, "Our finding shows that low membrane capacitance significantly improves the efficacy of signal processing and the speed of communication within and between cortical neurons in the human neocortex, as compared to rodents."

"The results of this work imply that human cortical neurons are efficient electrical microchips, compensating for the larger brain and large cells in humans, and processing sensory information more effectively," said Prof. Idan Segev from the Department of Neurobiology and the Edmond and Lily Safra Center for Brain Sciences at the Hebrew University.

"Indeed, the study shows that already at the level of the individual building blocks of the nervous system (the nerve cells), humans are distinct as compared to rodents. More research should be performed in this direction on non-human primates."

The researchers suggest the distinctive biophysical membrane properties of human pyramidal neurons are an outcome of evolutionary pressure to compensate for the increase in size and distances in the human brain.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Alarming Cesarean Section Trends in India - Convenience or Compulsion of Corporate Healthcare
Quiz on Low-Calorie Diet for Diabetes
World Heart Day in 2022- Use Heart for Every Heart
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Parkinsons Disease Parkinsons Disease Surgical Treatment 

Most Popular on Medindia

Blood Donation - Recipients Sanatogen Drug Side Effects Calculator Pregnancy Confirmation Calculator Hearing Loss Calculator Find a Hospital Daily Calorie Requirements Loram (2 mg) (Lorazepam) Blood Pressure Calculator The Essence of Yoga
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Unique Membrane Properties of Human Neocortical Neurons Enhance Signal Processing Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests