Medindia
Advertisement

Unexpected Deaths Due to High-dose Antipsychotics

by Ramya Rachamanti on December 13, 2018 at 10:44 AM
Font : A-A+

Unexpected Deaths Due to High-dose Antipsychotics

Children and young adult patients who were not psychotic but using high-dose antipsychotic drugs are at high risk of facing unexpected deaths despite access to other drugs to treat their clinical conditions, according to a Vanderbilt University Medical Center study published in JAMA Psychiatry.

Unexpected death includes deaths due to unintentional drug overdose or cardiovascular/metabolic causes.

Advertisement


In 2010, an estimated 1.3 million individuals 24 years of age or younger filled 7 million prescriptions, primarily for behavioral symptoms (such as ADHD), depression or bipolar disorders. However, antipsychotics have potentially life-threatening effects, even in younger populations, and there are other medications for many of these conditions.

The findings reinforce guidelines for cautious use of antipsychotics in younger populations, according to senior author Wayne Ray, PhD, professor of Health Policy at Vanderbilt University School of Medicine.
Advertisement

"Patients should be selected very carefully, after consideration of both drug- and non-drug-alternatives," Ray said. "There should be a pre-treatment evaluation for factors that might amplify antipsychotic effects, such as cardiac conditions. These children and young adults should also be thoroughly monitored during treatment if they are prescribed a high-dose antipsychotic."

Study authors searched data for about 250,000 relatively healthy children and young people (ages 5 to 24) enrolled in the Tennessee Medicaid program from January 1999 through December 2014, including new users of antipsychotic medications who received higher or lower doses and a comparison group of new users of control medications that weren't antipsychotics.

Patients with schizophrenia or other psychoses were excluded because there are no alternatives to antipsychotics for these conditions.

The high-dose antipsychotic group of children and young adults ages 5-24 had a 3.5-fold increased risk of unexpected death, when compared with their peers in the study, while the risk for cardiovascular and metabolic deaths was increased 4.3-fold.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Gonorrhea
World Alzheimer's Day 2021 - 'Know Dementia, Know Alzheimer's
'Hybrid Immunity' may Help Elude COVID-19 Pandemic
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Bereavement 

Recommended Reading
Antipsychotic Medications
Antipsychotics are the class of drugs which help in treating mental disorders like schizophrenia, .....
Bereavement
Bereavement refers to grief, pain and sadness following the loss of a loved one, especially during t...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use