About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Understanding the Mechanism for Spread of Metastatic Breast Cancer to Bone

by Dr. Trupti Shirole on November 7, 2016 at 10:47 PM
Font : A-A+

 Understanding the Mechanism for Spread of Metastatic Breast Cancer to Bone

Metastatic breast cancer cells might use bone marrow-derived mesenchymal stem cells (MSCs) to help them spread to bone tissue.  A study using a 3D scaffold model has shown how this happens.

The findings suggest that breast tumor-derived factors can promote the maturation of MSCs into bone cells, and that mechanical compression of the scaffold further stimulates bone development. The article is published in Tissue Engineering.

Advertisement


Maureen Lynch, Claudia Fischbach, and coauthors from Cornell University (Ithaca, NY) and University of Massachusetts Amherst used a mineral-containing 3D scaffold as an in vitro model to study whether factors such as breast tumor-derived compounds and mechanical stimulation within the bone microenvironment affect the interactions between metastatic cancer cells and bone.

Understanding and intervening in these interactions could have clinical implications for the nearly 75% of patients with advanced breast cancer in whom incurable skeletal metastatic disease develops.
Advertisement

The article entitled "Three-Dimensional Mechanical Loading Modulates the Osteogenic Response of Mesenchymal Stem Cells to Tumor-Derived Soluble Signals" describes the composition of the scaffold, the study design, and how this model can be used to evaluate the role of certain physical cues on bone metastatic breast cancer.

"The article reports a very exciting study leveraging a tissue-engineered tumor model for controlled interrogation of tumor-bone interactions with enormous implications for the development of new therapeutics" says Co-Editor-in-Chief Antonios G. Mikos, Louis Calder Professor at Rice University, Houston, TX.

Source: Eurekalert
Advertisement

Advertisement
Advertisement

Recommended Reading

Latest Cancer News

 Myelofibrosis: New Drugs to Revolutionize Treatment
The approvals of pipeline drugs such as momelotinib and Vonjo for myelofibrosis (a rare type of blood cancer) over some time will handle the critical unmet needs.
 Blood Vessels Can Kill Cancer Cells and Stop Breast Cancer Spread
New study highlights the dual role that blood vessels can play in cancer immunotherapy and eliciting anti-tumor immune responses or even preventing breast cancer spread.
 Weed Killer Agent Orange May Increase the Risk of Blood Cancer Among Veterans
New study evaluated the association between exposure to the chemical agent orange and the development of blood cancer with increased bleeding and blood clot formation.
Two Years: Optimal Duration of Immunotherapy in Advanced Lung Cancer
Study suggests two-year immunotherapy treatment for advanced lung cancer may be reasonable
Hope for Lethal Brain Tumors: Targeted Therapy Delays Glioma Progression
A ray of hope for glioma patients as targeted therapy boosts treatment duration.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Understanding the Mechanism for Spread of Metastatic Breast Cancer to Bone Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests