Understanding Immune Responses of Commonly Prescribed Medications

Immune responses of commonly prescribed medications were understood by activating drugs that activate a specialised type of immune cell, MAIT cell.

Some drugs can unpredictably impact the functioning of the immune system. Most of the drugs used in the treatment of various diseases are often accompanied by harmful side effects.//

A research team from Australia has now moved to one step closer, by understanding the immune sensitivities to well-known and commonly prescribed medications.

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‘Understanding the immune responses of MAIT cells (Mucosal associated invariant T cell) in drug therapies may improve clinical outcome.’

The team investigated what drugs might activate a specialised type of immune cell, the MAIT cell (Mucosal associated invariant T cell). They found that some drugs prevented the MAIT cells from detecting infections (their main role in our immune system), while other drugs activated the immune system, which may be undesirable.

The results, published in Nature Immunology overnight, may lead to a much better understanding of, and an explanation for, immune reactions by some people to certain kinds of drugs. The findings may also offer a way to control the actions of MAIT cells in certain illnesses for more positive patient outcomes.

The multidisciplinary team of researchers are part of the ARC Centre of Excellence in Advanced Molecular Imaging, and stem from Monash University, The University of Melbourne and The University of Queensland. Access to national research infrastructure, including the Australian synchrotron, was instrumental to the success of this Australian research team.

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Dr Andrew Keller from Monash University's Biomedicine Discovery Institute said that T cells are an integral part of the body's immune system.

"They protect the body by 'checking' other cells for signs of infection and activating the immune system when they detect an invader," he said.

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"This arrangement is dependent on both the T cells knowing what they're looking for, and the other cells in the body giving them useful information."

PhD student Weijun Xu from The University of Queensland's Institute for Molecular Bioscience used computer modelling to predict chemical structures, drugs and drug-like molecules that might impact on MAIT cell function. Such small compounds included salicylates, non-steroidal anti-inflammatory drugs like diclofenac, and drug metabolites.

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University of Melbourne Dr Sidonia Eckle from the Peter Doherty Institute for Infection and Immunity said the implications point to possible links between known drug hypersensitivities and MAIT cells.

"A greater understanding of the interaction between MAIT cells and other host cells will hopefully allow us to better predict and avoid therapeutics that influence and cause harm," she said.

"It also offers the tantalising prospect of future therapies that manipulate MAIT cell behavior, for example, by enhancing or suppressing immune responses to achieve beneficial clinical outcome."

Source-Eurekalert