About Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Understanding How an Influenza Vaccine Works

by Hannah Joy on February 19, 2018 at 7:50 PM
Font : A-A+

Understanding How an Influenza Vaccine Works

Understanding as to how the body builds immunity aids in building better influenza vaccines, reveals a new study.

Scientists say their findings could help guide better vaccine development, because understanding the cellular basis for protective immunity is critical for creating effective immunizations.

Advertisement


Even though influenza vaccination is well-established as the most effective strategy to prevent people from becoming sickened with seasonal flu, many details about how the immune system fends off the virus and protects the body remain mysterious.

Here, Marios Koutsakos and colleagues closely examined how different types of immune cells respond to vaccines. They analyzed blood samples from 35 healthy adults at several time-points during a three-year period following immunization.
Advertisement

Beginning one week after vaccination, Koutsakos et al. noted a marked increase in antibody-producing B cells programmed to fight against specific components of the corresponding year's flu shots.

A similar pattern emerged for another group of cells called circulating T follicular helper cells (cTfh) providing new insight about their ability to generate long-lasting immune memory.

The presence of pre-existing anti-flu antibodies prior to vaccination in study participants' blood dampened B cell responses.

After one year, flu-specific B cells were no longer detected in the blood prompting the researchers to analyze tissues from deceased organ donors (which allowed them to track down memory B cells in the lungs, tonsils, spleens, and lymph nodes).

The authors speculate that the migration of flu-specific B cells to different tissues could have implications for the ideal inoculation route, and that intranasal vaccination might be more effective than injections.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Prevent Hacking of Medical Devices: FDA Sounds Alarm
Black Water: Benefits and Uses
World Hypertension Day 2022 - Measure Blood Pressure Accurately, Control It, Live Longer!
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Hib Vaccine Flu Swine Flu Anal Warts Reye’s Syndrome Vaccination for Children Preventing Flu: Good Health Habits Can Help Stop Germs Top 10 Vaccine Myths Debunked Ways to Boost Your Immune System during Cold and Flu Season 

Most Popular on Medindia

How to Reduce School Bag Weight - Simple Tips Find a Hospital Accident and Trauma Care Drug Interaction Checker Diaphragmatic Hernia Drug Side Effects Calculator Noscaphene (Noscapine) Hearing Loss Calculator Pregnancy Confirmation Calculator Sinopril (2mg) (Lacidipine)

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use