About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Understanding Gender Disparity in the Prognosis of Melanoma

by Dr. Trupti Shirole on December 17, 2016 at 10:41 AM
Font : A-A+

 Understanding Gender Disparity in the Prognosis of Melanoma

Men who get melanoma are twice as likely to die from the disease as women. However, the biological explanation for this is poorly understood.

Research led by Dr. Alan Spatz, Director of Surgical and Molecular Pathology at the Jewish General Hospital and head of the "X chromosome and cancer" lab at the Lady Davis Institute in Montreal, reveals that the decreased expression of the X chromosome gene PPP2R3B and its protein PR70 are positively linked to tumor progression in this aggressive form of skin cancer.

Advertisement


The finding is published in Science Translational Medicine.

"We focused our research on the machinery of the X chromosome because we postulated that the inactivation of one of the two X chromosomes in women, as opposed to men who have an X and a Y, and the way this mechanism is regulated, may have deep implications on the cell biology of cancer cells" explains Dr. Spatz, who has a long-standing interest in the role of the X chromosome in cancer.
Advertisement

"I proposed in 2004 a theoretical model of X-linked tumor suppressor genes loss and oncogenes activation that since has been validated in many situations. The fact that two X's interact together in females has also implications for cancer. We believe that the genetic specificity of the X chromosome plays a significant function in the gender difference we observe in melanoma. And we see unique regulation of tumor suppressor genes and oncogenes in the X chromosome."

Dr. Spatz, Professor of Pathology and Oncology at McGill University, and Dr. Leon van Kempen, COO and Scientific Director Molecular Pathology Center, have extensively studied the gene PPP2R3B, which is located on the X chromosome in females, but on the Y in males.

The expression of this gene has been independently correlated with more favorable progression in melanoma and is important because its expression is higher in females. PPP2R3B codes for the PR70 protein, which decreases melanoma growth by negatively interfering with DNA cell replication and, therefore, acting as an X-linked tumor suppressor.

PR70 is at the forefront of controlling the cell replication cascade. From a clinical perspective, this research suggests there could be potential anti-cancer therapies in actioning the proteins linked to PR70. The proteomics capabilities that have been developed at the Segal Cancer Center and Lady Davis Institute at the Jewish General Hospital will eventually be instrumental in profiling and identifying the active proteins that could be most effectively targeted by novel therapies.

"I believe this discovery advances our understanding of the specific role of the X chromosome genetics in modulating the expression of genes that are critical in cancer progression," Dr. Spatz said. "Specifically, this is a new avenue for exploring X-linked tumor suppressor genes and oncogenes. I'm confident that we will eventually be able to exploit this discovery to pursue new therapeutic avenues against cancer."

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
H1N1 Influenza Prevention in Children: What Parents Need to Know
Dietary Factors Responsible for Dihydrotestosterone (DHT) Production and Hair Loss
Test Your Knowledge About Chromosomes?
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Ultra-Violet Radiation Melanoma 

Most Popular on Medindia

Iron Intake Calculator Find a Hospital Drug Interaction Checker Sinopril (2mg) (Lacidipine) Hearing Loss Calculator Post-Nasal Drip Noscaphene (Noscapine) Diaphragmatic Hernia Selfie Addiction Calculator Daily Calorie Requirements
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Understanding Gender Disparity in the Prognosis of Melanoma Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests